Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway

Diabetes mellitus is characterized by cytokine-induced insulitis and a deficit in beta-cell mass. Ligands for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) have been shown to have anti-inflammatory effects in various experimental models. We questioned whether activation of endogenous...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The international journal of biochemistry & cell biology 2007, Vol.39 (6), p.1260
Hauptverfasser:	Kim, Eun-Kyung, Kwon, Kang-Beom, Koo, Bon-Sun, Han, Mi-Jeong, Song, Mi-Young, Song, Eun-Kyung, Han, Myung-Kwan, Park, Jin-Woo, Ryu, Do-Gon, Park, Byung-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Blotting, Western Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chromans - pharmacology Cytokines - pharmacology Dinoprostone - metabolism Dose-Response Relationship, Drug Electrophoretic Mobility Shift Assay I-kappa B Proteins - genetics I-kappa B Proteins - metabolism Insulin - metabolism Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Interleukin-1beta - pharmacology Male Mutation NF-kappa B - metabolism NF-KappaB Inhibitor alpha Nitrites - metabolism PPAR gamma - genetics PPAR gamma - metabolism Rats Rats, Sprague-Dawley Signal Transduction - drug effects Thiazolidinediones - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!