Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in hepG2
The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cdsup(2+)) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cdsup(2+). These results suggest that Cdsup(...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-05, Vol.71 (5), p.1334-1337 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Oishi, Y.(Tokyo Univ. of Agriculture (Japan). Faculty of Applied Bio-Science) Ohnishi, M Kobayashi Hattori, K Takita, T Noguchi, T |
| description | The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cdsup(2+)) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cdsup(2+). These results suggest that Cdsup(2+) impacts the gene expression of IGFBP-1, which leads to production of IGFBP-1. |
| doi_str_mv | 10.1271/bbb.60679 |
| format | Article |
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Faculty of Applied Bio-Science) ; Ohnishi, M ; Kobayashi Hattori, K ; Takita, T ; Noguchi, T</creator><creatorcontrib>Oishi, Y.(Tokyo Univ. of Agriculture (Japan). Faculty of Applied Bio-Science) ; Ohnishi, M ; Kobayashi Hattori, K ; Takita, T ; Noguchi, T</creatorcontrib><description>The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cdsup(2+)) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cdsup(2+). These results suggest that Cdsup(2+) impacts the gene expression of IGFBP-1, which leads to production of IGFBP-1.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.60679</identifier><identifier>PMID: 17485842</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>ALIMENTOS ; ARN ; BINDING PROTEINS ; Biological and medical sciences ; CADMIO ; CADMIUM ; Cadmium - pharmacology ; cadmium cation ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; CATION ; CATIONES ; CATIONS ; Cations - pharmacology ; Cell Line, Tumor ; Cell Survival - drug effects ; Dose-Response Relationship, Drug ; EXPRESION GENICA ; EXPRESSION DES GENES ; FACTEUR DE CROISSANCE IGF ; FACTOR DE CRECIMIENTO IGF ; FOODS ; Formazans - metabolism ; Fundamental and applied biological sciences. Psychology ; GENE EXPRESSION ; HepG2 ; Humans ; INSULIN-LIKE GROWTH FACTOR ; Insulin-Like Growth Factor Binding Protein 1 - biosynthesis ; insulin-like growth factor-binding protein-1 (IGFBP-1) ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; PRODUIT ALIMENTAIRE ; PROTEINAS AGLUTINANTES ; PROTEINE DE LIAISON ; RNA ; RNA, Messenger - metabolism ; Tetrazolium Salts - metabolism ; Time Factors</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2007-05, Vol.71 (5), p.1334-1337</ispartof><rights>2007 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2007</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c635t-320298093a52f3eb5da082f99bb3a49c76857e2f4b7be75b054fb90a49f719bf3</citedby><cites>FETCH-LOGICAL-c635t-320298093a52f3eb5da082f99bb3a49c76857e2f4b7be75b054fb90a49f719bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18879108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17485842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oishi, Y.(Tokyo Univ. of Agriculture (Japan). Faculty of Applied Bio-Science)</creatorcontrib><creatorcontrib>Ohnishi, M</creatorcontrib><creatorcontrib>Kobayashi Hattori, K</creatorcontrib><creatorcontrib>Takita, T</creatorcontrib><creatorcontrib>Noguchi, T</creatorcontrib><title>Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in hepG2</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cdsup(2+)) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cdsup(2+). These results suggest that Cdsup(2+) impacts the gene expression of IGFBP-1, which leads to production of IGFBP-1.</description><subject>ALIMENTOS</subject><subject>ARN</subject><subject>BINDING PROTEINS</subject><subject>Biological and medical sciences</subject><subject>CADMIO</subject><subject>CADMIUM</subject><subject>Cadmium - pharmacology</subject><subject>cadmium cation</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>CATION</subject><subject>CATIONES</subject><subject>CATIONS</subject><subject>Cations - pharmacology</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>EXPRESION GENICA</subject><subject>EXPRESSION DES GENES</subject><subject>FACTEUR DE CROISSANCE IGF</subject><subject>FACTOR DE CRECIMIENTO IGF</subject><subject>FOODS</subject><subject>Formazans - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE EXPRESSION</subject><subject>HepG2</subject><subject>Humans</subject><subject>INSULIN-LIKE GROWTH FACTOR</subject><subject>Insulin-Like Growth Factor Binding Protein 1 - biosynthesis</subject><subject>insulin-like growth factor-binding protein-1 (IGFBP-1)</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>PRODUIT ALIMENTAIRE</subject><subject>PROTEINAS AGLUTINANTES</subject><subject>PROTEINE DE LIAISON</subject><subject>RNA</subject><subject>RNA, Messenger - metabolism</subject><subject>Tetrazolium Salts - metabolism</subject><subject>Time Factors</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0VtrFDEUAOAgil2rD_4AJSAKPkzNdTJ5LItWpaiIPockk-ymZpJtMmPpvzfbXSmIT4Gc71w4B4DnGJ1hIvA7Y8xZj3ohH4AVpkx0vWTiIVghiftuYByfgCe1XiHUPjh-DE6wYAMfGFmB3VqPU1gmaPUccoIh2eJ0dRXOWwd3JY-LvQvoNMLp-5dzGN1vFyvMvtm6xJC6GH45uCn5Zt5Cr-2cS2dCGkPa7AvMrhHcMNy63QV5Ch55Hat7dnxPwc8P73-sP3aXXy8-rc8vO9tTPneUICIHJKnmxFNn-KjRQLyUxlDNpBX9wIUjnhlhnOAGceaNRC3kBZbG01Pw5lC3jXC9uDqrKVTrYtTJ5aUqgTgWkuAGX_0Dr_JSUptNYcbkgHvJh6beHpQtudbivNqVMOlyqzBS-yOodgR1d4RmXx4rLmZy4708br2B10egq9XRF51sqPduGITEaN-UHVxIPpdJ3-QSRzXr25jL3yT6v_4vDmleZ6U3panP3whCAqGeEkb_AAFVqSQ</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Oishi, Y.(Tokyo Univ. of Agriculture (Japan). Faculty of Applied Bio-Science)</creator><creator>Ohnishi, M</creator><creator>Kobayashi Hattori, K</creator><creator>Takita, T</creator><creator>Noguchi, T</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in hepG2</title><author>Oishi, Y.(Tokyo Univ. of Agriculture (Japan). Faculty of Applied Bio-Science) ; Ohnishi, M ; Kobayashi Hattori, K ; Takita, T ; Noguchi, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c635t-320298093a52f3eb5da082f99bb3a49c76857e2f4b7be75b054fb90a49f719bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>ALIMENTOS</topic><topic>ARN</topic><topic>BINDING PROTEINS</topic><topic>Biological and medical sciences</topic><topic>CADMIO</topic><topic>CADMIUM</topic><topic>Cadmium - pharmacology</topic><topic>cadmium cation</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>CATION</topic><topic>CATIONES</topic><topic>CATIONS</topic><topic>Cations - pharmacology</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>EXPRESION GENICA</topic><topic>EXPRESSION DES GENES</topic><topic>FACTEUR DE CROISSANCE IGF</topic><topic>FACTOR DE CRECIMIENTO IGF</topic><topic>FOODS</topic><topic>Formazans - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE EXPRESSION</topic><topic>HepG2</topic><topic>Humans</topic><topic>INSULIN-LIKE GROWTH FACTOR</topic><topic>Insulin-Like Growth Factor Binding Protein 1 - biosynthesis</topic><topic>insulin-like growth factor-binding protein-1 (IGFBP-1)</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>PRODUIT ALIMENTAIRE</topic><topic>PROTEINAS AGLUTINANTES</topic><topic>PROTEINE DE LIAISON</topic><topic>RNA</topic><topic>RNA, Messenger - metabolism</topic><topic>Tetrazolium Salts - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oishi, Y.(Tokyo Univ. of Agriculture (Japan). Faculty of Applied Bio-Science)</creatorcontrib><creatorcontrib>Ohnishi, M</creatorcontrib><creatorcontrib>Kobayashi Hattori, K</creatorcontrib><creatorcontrib>Takita, T</creatorcontrib><creatorcontrib>Noguchi, T</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oishi, Y.(Tokyo Univ. of Agriculture (Japan). Faculty of Applied Bio-Science)</au><au>Ohnishi, M</au><au>Kobayashi Hattori, K</au><au>Takita, T</au><au>Noguchi, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in hepG2</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>71</volume><issue>5</issue><spage>1334</spage><epage>1337</epage><pages>1334-1337</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cdsup(2+)) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cdsup(2+). 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| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2007-05, Vol.71 (5), p.1334-1337 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_pubmed_primary_17485842 |
| source | J-STAGE Free; MEDLINE; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | ALIMENTOS ARN BINDING PROTEINS Biological and medical sciences CADMIO CADMIUM Cadmium - pharmacology cadmium cation Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology CATION CATIONES CATIONS Cations - pharmacology Cell Line, Tumor Cell Survival - drug effects Dose-Response Relationship, Drug EXPRESION GENICA EXPRESSION DES GENES FACTEUR DE CROISSANCE IGF FACTOR DE CRECIMIENTO IGF FOODS Formazans - metabolism Fundamental and applied biological sciences. Psychology GENE EXPRESSION HepG2 Humans INSULIN-LIKE GROWTH FACTOR Insulin-Like Growth Factor Binding Protein 1 - biosynthesis insulin-like growth factor-binding protein-1 (IGFBP-1) Liver Neoplasms - metabolism Liver Neoplasms - pathology PRODUIT ALIMENTAIRE PROTEINAS AGLUTINANTES PROTEINE DE LIAISON RNA RNA, Messenger - metabolism Tetrazolium Salts - metabolism Time Factors |
| title | Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in hepG2 |
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