Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in hepG2

The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cdsup(2+)) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cdsup(2+). These results suggest that Cdsup(...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-05, Vol.71 (5), p.1334-1337
Hauptverfasser:	Oishi, Y.(Tokyo Univ. of Agriculture (Japan). Faculty of Applied Bio-Science), Ohnishi, M, Kobayashi Hattori, K, Takita, T, Noguchi, T
Format:	Artikel
Sprache:	eng
Schlagworte:	ALIMENTOS ARN BINDING PROTEINS Biological and medical sciences CADMIO CADMIUM Cadmium - pharmacology cadmium cation Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology CATION CATIONES CATIONS Cations - pharmacology Cell Line, Tumor Cell Survival - drug effects Dose-Response Relationship, Drug EXPRESION GENICA EXPRESSION DES GENES FACTEUR DE CROISSANCE IGF FACTOR DE CRECIMIENTO IGF FOODS Formazans - metabolism Fundamental and applied biological sciences. Psychology GENE EXPRESSION HepG2 Humans INSULIN-LIKE GROWTH FACTOR Insulin-Like Growth Factor Binding Protein 1 - biosynthesis insulin-like growth factor-binding protein-1 (IGFBP-1) Liver Neoplasms - metabolism Liver Neoplasms - pathology PRODUIT ALIMENTAIRE PROTEINAS AGLUTINANTES PROTEINE DE LIAISON RNA RNA, Messenger - metabolism Tetrazolium Salts - metabolism Time Factors
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Zusammenfassung:	The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cdsup(2+)) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cdsup(2+). These results suggest that Cdsup(2+) impacts the gene expression of IGFBP-1, which leads to production of IGFBP-1.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.60679