Oral cefadroxil prophylaxis in hip fracture surgery: Serum concentrations studied in 17 patients

Oral cefadroxil prophylaxis in hip fracture surgery: Serum concentrations studied in 17 patients

Serum concentration-time curves were determined in seventeen 82 (60-90) year-old patients undergoing trochanteric hip fracture surgery after receiving 1 g of cefadroxil per os. All the patients attained a serum level of antibiotic high enough to inhibit the growth of Staphylococcus aureus and S. epi...

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Veröffentlicht in:Acta orthopaedica Scandinavica 1992-02, Vol.63 (1), p.4-6
Hauptverfasser: Nungu, Kitugi Samwel, Bengtsson, Stellan, Olerud, Claes, Rehnberg, Lars, Larsson, Sune
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cefadroxil - blood
Cefadroxil - therapeutic use
Female
Hip Fractures - surgery
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Premedication
Staphylococcus aureus - drug effects
Staphylococcus epidermidis - drug effects
Surgical Wound Infection - prevention & control
Time Factors
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Zusammenfassung:Serum concentration-time curves were determined in seventeen 82 (60-90) year-old patients undergoing trochanteric hip fracture surgery after receiving 1 g of cefadroxil per os. All the patients attained a serum level of antibiotic high enough to inhibit the growth of Staphylococcus aureus and S. epidermidis. When orally administered, cefadroxil should be given within 2 hours before surgery. Serum concentrations studied in 17 patients
ISSN:0001-6470
DOI:10.3109/17453679209154839