The use of hydroxy acids on the skin: characteristics of C8-lipohydroxy acid
Summary The hydroxy acids are widely used in skin creams because of their exfoliating and rejuvenating effect on photoaged skin. As a member of this family, the salicylic acid derivative known in the literature as 2‐hydroxy‐5‐octanoyl benzoic acid or β‐lipohydroxy acid has also been proposed as an e...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2007-03, Vol.6 (1), p.59-65 |
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| container_title | Journal of cosmetic dermatology |
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| creator | Saint-Léger, Didier Lévêque, Jean-Luc Verschoore, Michèle |
| description | Summary
The hydroxy acids are widely used in skin creams because of their exfoliating and rejuvenating effect on photoaged skin. As a member of this family, the salicylic acid derivative known in the literature as 2‐hydroxy‐5‐octanoyl benzoic acid or β‐lipohydroxy acid has also been proposed as an exfoliant and as a treatment of photoaged skin and acne. This article reviews the effects of the hydroxy acids and compares them to those of the salicylic acid derivative. We propose the name C8‐lipohydroxy acid (C8‐LHA) for this derivative to differentiate it from other related compounds. The lipophilic nature of C8‐LHA and its relatively slow penetration in the skin afford it an exfoliating effect that is efficient at low concentrations. It appears to have antimicrobial, anti‐inflammatory, and anticomedogenic properties, which make it effective against acne. Its antifungal and exfoliating properties are also likely to prove useful in combating dandruff. |
| doi_str_mv | 10.1111/j.1473-2165.2007.00296.x |
| format | Article |
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The hydroxy acids are widely used in skin creams because of their exfoliating and rejuvenating effect on photoaged skin. As a member of this family, the salicylic acid derivative known in the literature as 2‐hydroxy‐5‐octanoyl benzoic acid or β‐lipohydroxy acid has also been proposed as an exfoliant and as a treatment of photoaged skin and acne. This article reviews the effects of the hydroxy acids and compares them to those of the salicylic acid derivative. We propose the name C8‐lipohydroxy acid (C8‐LHA) for this derivative to differentiate it from other related compounds. The lipophilic nature of C8‐LHA and its relatively slow penetration in the skin afford it an exfoliating effect that is efficient at low concentrations. It appears to have antimicrobial, anti‐inflammatory, and anticomedogenic properties, which make it effective against acne. Its antifungal and exfoliating properties are also likely to prove useful in combating dandruff.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/j.1473-2165.2007.00296.x</identifier><identifier>PMID: 17348998</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Administration, Cutaneous ; antibacterial ; comedolytic ; epidermal stimulation ; exfoliation ; Facial Dermatoses - drug therapy ; Facial Dermatoses - pathology ; Female ; Follow-Up Studies ; Humans ; hydroxy acid ; Hydroxy Acids - chemistry ; Hydroxy Acids - therapeutic use ; Male ; Risk Assessment ; Salicylates - chemistry ; Salicylates - therapeutic use ; Sensitivity and Specificity ; Skin Absorption ; Skin Aging - drug effects ; Skin Aging - pathology ; Skin Diseases - diagnosis ; Skin Diseases - drug therapy ; Skin Irritancy Tests ; Treatment Outcome</subject><ispartof>Journal of cosmetic dermatology, 2007-03, Vol.6 (1), p.59-65</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1473-2165.2007.00296.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1473-2165.2007.00296.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17348998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saint-Léger, Didier</creatorcontrib><creatorcontrib>Lévêque, Jean-Luc</creatorcontrib><creatorcontrib>Verschoore, Michèle</creatorcontrib><title>The use of hydroxy acids on the skin: characteristics of C8-lipohydroxy acid</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Summary
The hydroxy acids are widely used in skin creams because of their exfoliating and rejuvenating effect on photoaged skin. As a member of this family, the salicylic acid derivative known in the literature as 2‐hydroxy‐5‐octanoyl benzoic acid or β‐lipohydroxy acid has also been proposed as an exfoliant and as a treatment of photoaged skin and acne. This article reviews the effects of the hydroxy acids and compares them to those of the salicylic acid derivative. We propose the name C8‐lipohydroxy acid (C8‐LHA) for this derivative to differentiate it from other related compounds. The lipophilic nature of C8‐LHA and its relatively slow penetration in the skin afford it an exfoliating effect that is efficient at low concentrations. It appears to have antimicrobial, anti‐inflammatory, and anticomedogenic properties, which make it effective against acne. Its antifungal and exfoliating properties are also likely to prove useful in combating dandruff.</description><subject>Administration, Cutaneous</subject><subject>antibacterial</subject><subject>comedolytic</subject><subject>epidermal stimulation</subject><subject>exfoliation</subject><subject>Facial Dermatoses - drug therapy</subject><subject>Facial Dermatoses - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>hydroxy acid</subject><subject>Hydroxy Acids - chemistry</subject><subject>Hydroxy Acids - therapeutic use</subject><subject>Male</subject><subject>Risk Assessment</subject><subject>Salicylates - chemistry</subject><subject>Salicylates - therapeutic use</subject><subject>Sensitivity and Specificity</subject><subject>Skin Absorption</subject><subject>Skin Aging - drug effects</subject><subject>Skin Aging - pathology</subject><subject>Skin Diseases - diagnosis</subject><subject>Skin Diseases - drug therapy</subject><subject>Skin Irritancy Tests</subject><subject>Treatment Outcome</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRS0EoqXwC8g_kOBHYjtILFAohRIoSEUsLcdxVPeVKm5F8vc4FAqzmZHuvaOZAwDEKMS-ruYhjjgNCGZxSBDiIUIkYWFzBPoH4fgwU9QDZ87NEcI8wfEp6GFOI5Ekog-y6czAnTOwKuGsLeqqaaHStnCwWsOt19zCrq-hnqla6a2prdta7Tp3KoKl3VT_Q-fgpFRLZy5--gC83w-n6UOQTUaP6W0WWH8YC5ghOdaaCY0N07EuBM5VIeJcMEJYkaMIea3EkTY4EiVSvOSCGJNEpeacEjoAl_u9m12-MoXc1Hal6lb-vuUNN3vDp12a9k9HssMn57IjIztKssMnv_HJRo4n6Z2ffD7Y5_27pjnkVb2QjFMey4-XkXwax9krfxPymX4B8XlyLQ</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Saint-Léger, Didier</creator><creator>Lévêque, Jean-Luc</creator><creator>Verschoore, Michèle</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200703</creationdate><title>The use of hydroxy acids on the skin: characteristics of C8-lipohydroxy acid</title><author>Saint-Léger, Didier ; Lévêque, Jean-Luc ; Verschoore, Michèle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2166-6e2b1cc68c1e6c5cd81bad85b86226db04068cf14ce148f0a7f782ee94fc77323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Administration, Cutaneous</topic><topic>antibacterial</topic><topic>comedolytic</topic><topic>epidermal stimulation</topic><topic>exfoliation</topic><topic>Facial Dermatoses - drug therapy</topic><topic>Facial Dermatoses - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>hydroxy acid</topic><topic>Hydroxy Acids - chemistry</topic><topic>Hydroxy Acids - therapeutic use</topic><topic>Male</topic><topic>Risk Assessment</topic><topic>Salicylates - chemistry</topic><topic>Salicylates - therapeutic use</topic><topic>Sensitivity and Specificity</topic><topic>Skin Absorption</topic><topic>Skin Aging - drug effects</topic><topic>Skin Aging - pathology</topic><topic>Skin Diseases - diagnosis</topic><topic>Skin Diseases - drug therapy</topic><topic>Skin Irritancy Tests</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saint-Léger, Didier</creatorcontrib><creatorcontrib>Lévêque, Jean-Luc</creatorcontrib><creatorcontrib>Verschoore, Michèle</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saint-Léger, Didier</au><au>Lévêque, Jean-Luc</au><au>Verschoore, Michèle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of hydroxy acids on the skin: characteristics of C8-lipohydroxy acid</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2007-03</date><risdate>2007</risdate><volume>6</volume><issue>1</issue><spage>59</spage><epage>65</epage><pages>59-65</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Summary
The hydroxy acids are widely used in skin creams because of their exfoliating and rejuvenating effect on photoaged skin. As a member of this family, the salicylic acid derivative known in the literature as 2‐hydroxy‐5‐octanoyl benzoic acid or β‐lipohydroxy acid has also been proposed as an exfoliant and as a treatment of photoaged skin and acne. This article reviews the effects of the hydroxy acids and compares them to those of the salicylic acid derivative. We propose the name C8‐lipohydroxy acid (C8‐LHA) for this derivative to differentiate it from other related compounds. The lipophilic nature of C8‐LHA and its relatively slow penetration in the skin afford it an exfoliating effect that is efficient at low concentrations. It appears to have antimicrobial, anti‐inflammatory, and anticomedogenic properties, which make it effective against acne. Its antifungal and exfoliating properties are also likely to prove useful in combating dandruff.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17348998</pmid><doi>10.1111/j.1473-2165.2007.00296.x</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 1473-2130 |
| ispartof | Journal of cosmetic dermatology, 2007-03, Vol.6 (1), p.59-65 |
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| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Administration, Cutaneous antibacterial comedolytic epidermal stimulation exfoliation Facial Dermatoses - drug therapy Facial Dermatoses - pathology Female Follow-Up Studies Humans hydroxy acid Hydroxy Acids - chemistry Hydroxy Acids - therapeutic use Male Risk Assessment Salicylates - chemistry Salicylates - therapeutic use Sensitivity and Specificity Skin Absorption Skin Aging - drug effects Skin Aging - pathology Skin Diseases - diagnosis Skin Diseases - drug therapy Skin Irritancy Tests Treatment Outcome |
| title | The use of hydroxy acids on the skin: characteristics of C8-lipohydroxy acid |
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