Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Copy Number

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2007-03, Vol.51 (3), p.1004-1010
Hauptverfasser:	CHARLES, R, NARAYAN, Shubha, VOSHOL, Hans, VAN OOSTRUM, Jan, WALL, Daniel, KOEHN, James, DZINK-FOX, Joann, RYDER, Neil S, RICHARDS, Joel, DAIGLE, Denis M, ESTEROW, Stacy, LEEDS, Jennifer A, KAMP, Heather, PUYANG, Xiaoling, WIEDMANN, Brigitte, MUELLER, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases Amidohydrolases - antagonists & inhibitors Amidohydrolases - biosynthesis Amidohydrolases - genetics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins Bacterial Proteins - biosynthesis Biological and medical sciences Blotting, Southern Chromosomes, Bacterial Chromosomes, Bacterial - genetics Culture Media DNA, Bacterial - genetics Electrophoresis, Polyacrylamide Gel Enzyme Inhibitors Enzyme Inhibitors - pharmacology Escherichia coli Proteins - genetics Gene Dosage Gene Expression Regulation, Enzymologic - drug effects Haemophilus influenzae Haemophilus influenzae - drug effects Hydrolysis Mechanisms of Resistance Medical sciences Microbial Sensitivity Tests Mutation - physiology Oligonucleotide Array Sequence Analysis Peptides Peptides - pharmacology Pharmacology. Drug treatments Repressor Proteins - genetics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Trypsin - chemistry
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Zusammenfassung:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.01103-06