Presbycusis: neural degeneration and aging on the auditory receptor of C57/BL6J mice

Presbycusis is a progressive hearing impairment associated with aging, characterized by hearing loss and a degeneration of cochlear structures. In this paper we analyze the effects of aging on the auditory system of C57/BL6J mice, with electrophysiological and morphological studies. With this aim th...

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Veröffentlicht in:	Acta otorrinolaringológica española 2006-11, Vol.57 (9), p.383
Hauptverfasser:	Castillo, E, Carricondo, F, Bartolomé, M V, Vicente-Torres, A, Poch Broto, J, Gil-Loyzaga, P
Format:	Artikel
Sprache:	spa
Schlagworte:	Aging - physiology Animals Cochlea - pathology Cochlea - physiopathology Female Hair Cells, Auditory - pathology Hair Cells, Auditory - physiopathology Male Mice Mice, Inbred C57BL Nerve Degeneration - complications Nerve Degeneration - pathology Nerve Degeneration - physiopathology Presbycusis - diagnosis Presbycusis - etiology Presbycusis - physiopathology
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Zusammenfassung:	Presbycusis is a progressive hearing impairment associated with aging, characterized by hearing loss and a degeneration of cochlear structures. In this paper we analyze the effects of aging on the auditory system of C57/BL6J mice, with electrophysiological and morphological studies. With this aim the auditory potentials of mice aging 1, 3, 6, 9, 12, 15, 18, 21 and 24 months were recorded, and then the morphology of the cochleal were analyzed. Auditory potentials revealed an increase in wave latencies, as well as a decrease in their amplitudes during aging. Morphological results showed a total Corti's organ degeneration, being replaced by a flat epithelial layer, and a total absence of hair cells.
ISSN:	0001-6519
DOI:	10.1016/S0001-6519(06)78734-9