Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic Sarcoidosis

Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.00...

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Veröffentlicht in:	Infection and Immunity 2007-01, Vol.75 (1), p.527-530
Hauptverfasser:	Drake, Wonder P, Dhason, Mary S, Nadaf, Michele, Shepherd, Bryan E, Vadivelu, Sangeetha, Hajizadeh, Rana, Newman, Lee S, Kalams, Spyros A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Bacterial - immunology Bacterial Proteins - immunology Biological and medical sciences Catalase - immunology Female Fundamental and applied biological sciences. Psychology Host Response and Inflammation Humans Leukocytes, Mononuclear - immunology Male Microbiology Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Sarcoidosis - complications Sarcoidosis - immunology T-Lymphocytes - immunology Tuberculin - immunology Tuberculosis - complications Tuberculosis - immunology
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Zusammenfassung:	Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.00732-06