$The activity and toxicity of low dose clofarabine against relapsed or refractory myeloma$

The activity and toxicity of low dose clofarabine against relapsed or refractory myeloma

Eight patients with refractory multiple myeloma were treated with clofarabine 4 mg/m2/day on days 1-5 of a 28 day cycle. No objective evidence of anti-myeloma activity was observed (median time to progression of 52 days). All patients experienced grade 3-4 neutropenia and a greater than 50% decrease...

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Veröffentlicht in:	Haematologica (Roma) 2006-11, Vol.91 (11), p.1581
Hauptverfasser:	Uy, GL, Tomasson, MH, Ruddell, A, DiPersio, JF, Vij, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - administration & dosage Adenine Nucleotides - adverse effects Adult Aged Arabinonucleosides - administration & dosage Arabinonucleosides - adverse effects Female Humans Male Middle Aged Multiple Myeloma - blood Multiple Myeloma - drug therapy Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - drug therapy Neutropenia - blood Neutropenia - chemically induced
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Zusammenfassung:	Eight patients with refractory multiple myeloma were treated with clofarabine 4 mg/m2/day on days 1-5 of a 28 day cycle. No objective evidence of anti-myeloma activity was observed (median time to progression of 52 days). All patients experienced grade 3-4 neutropenia and a greater than 50% decrease in platelet counts during treatment.
ISSN:	0390-6078 1592-8721