Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX
New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2006-09, Vol.16 (18), p.4852 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Oh, Kyung-Ae Yang, Garp Yeol Jun, Daniel Kuca, Kamil Jung, Young-Sik |
| description | New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent. |
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Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.</description><identifier>ISSN: 0960-894X</identifier><identifier>PMID: 16828550</identifier><language>eng</language><publisher>England</publisher><subject>Acetylcholinesterase - metabolism ; Cross-Linking Reagents - chemistry ; Ethers - chemistry ; Molecular Structure ; Organothiophosphorus Compounds - chemistry ; Oximes - chemical synthesis ; Oximes - chemistry ; Oximes - metabolism ; Pyridinium Compounds - chemical synthesis ; Pyridinium Compounds - chemistry ; Pyridinium Compounds - metabolism ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4852</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16828550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Kyung-Ae</creatorcontrib><creatorcontrib>Yang, Garp Yeol</creatorcontrib><creatorcontrib>Jun, Daniel</creatorcontrib><creatorcontrib>Kuca, Kamil</creatorcontrib><creatorcontrib>Jung, Young-Sik</creatorcontrib><title>Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. 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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4852 |
| issn | 0960-894X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholinesterase - metabolism Cross-Linking Reagents - chemistry Ethers - chemistry Molecular Structure Organothiophosphorus Compounds - chemistry Oximes - chemical synthesis Oximes - chemistry Oximes - metabolism Pyridinium Compounds - chemical synthesis Pyridinium Compounds - chemistry Pyridinium Compounds - metabolism Structure-Activity Relationship |
| title | Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX |
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