Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX

New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-09, Vol.16 (18), p.4852
Hauptverfasser:	Oh, Kyung-Ae, Yang, Garp Yeol, Jun, Daniel, Kuca, Kamil, Jung, Young-Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Cross-Linking Reagents - chemistry Ethers - chemistry Molecular Structure Organothiophosphorus Compounds - chemistry Oximes - chemical synthesis Oximes - chemistry Oximes - metabolism Pyridinium Compounds - chemical synthesis Pyridinium Compounds - chemistry Pyridinium Compounds - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.
ISSN:	0960-894X