Expression of FHIT in Esophageal Epithelium and Carcinoma: Reference to Drinking, Smoking and Multicentric Carcinogenesis
Background: Both alcohol consumption and cigarette smoking are risk factors for esophageal cancer. The purpose of this study was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in multicentric carcinogenesis. Patients and Methods: Th...
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| Veröffentlicht in: | Anticancer research 2006-05, Vol.26 (3B), p.2243-2248 |
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| creator | MORITA, Masaru OYAMA, Tsunehiro NAKATA, Shoji ONO, Kenji SUGAYA, Masakazu URAMOTO, Hidetaka YOSHIMATSU, Takashi HANAGIRI, Takeshi SUGIO, Kenji YASUMOTO, Kosei |
| description | Background: Both alcohol consumption and cigarette smoking are risk factors for esophageal cancer. The purpose of this study
was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in
multicentric carcinogenesis. Patients and Methods: The expression of FHIT was immunohistochemically examined in the squamous
cell carcinoma as well as in the normal esophageal epithelium of 55 cases with esophageal cancer. Results: The median drinking
indices (DIs) were 546 and 1092 (p |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_16821595</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16821595</sourcerecordid><originalsourceid>FETCH-LOGICAL-h270t-f7b77831d1605a5de4feaa09d86c1b19c5b71a7669edd8891b25390e1ebc5c5e3</originalsourceid><addsrcrecordid>eNpF0MFOwzAMBuAIgdgYvALKBU5USpqlabnB6NikISQY58pN3TXQplXSCfb2FMbEyT58_mX7iIy5SnigpGDHZMxCyQLFmByRM-_fGYuiJBanZMSjOOQykWOyS786h96b1tK2pPPFck2Npalvuwo2CDVNO9NXWJttQ8EWdAZOG9s2cEtfsESHViPtW_rgjP0wdnNDX5v2p_nVT9u6Nxpt74w-jG7Qojf-nJyUUHu8-KsT8jZP17NFsHp-XM7uVkEVKtYHpcqVigUveMQkyAKnJQKwpIgjzXOeaJkrDmq4DIsijhOeh1IkDDnmWmqJYkIu97ndNm-wyDpnGnC77PCDAVz9AfAa6tKB1cb_O5UwNh1WmJDrvavMpvo0DjPfQF0PsSIDF0aZuM_CcCrEN3NSdIk</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Expression of FHIT in Esophageal Epithelium and Carcinoma: Reference to Drinking, Smoking and Multicentric Carcinogenesis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>MORITA, Masaru ; OYAMA, Tsunehiro ; NAKATA, Shoji ; ONO, Kenji ; SUGAYA, Masakazu ; URAMOTO, Hidetaka ; YOSHIMATSU, Takashi ; HANAGIRI, Takeshi ; SUGIO, Kenji ; YASUMOTO, Kosei</creator><creatorcontrib>MORITA, Masaru ; OYAMA, Tsunehiro ; NAKATA, Shoji ; ONO, Kenji ; SUGAYA, Masakazu ; URAMOTO, Hidetaka ; YOSHIMATSU, Takashi ; HANAGIRI, Takeshi ; SUGIO, Kenji ; YASUMOTO, Kosei</creatorcontrib><description>Background: Both alcohol consumption and cigarette smoking are risk factors for esophageal cancer. The purpose of this study
was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in
multicentric carcinogenesis. Patients and Methods: The expression of FHIT was immunohistochemically examined in the squamous
cell carcinoma as well as in the normal esophageal epithelium of 55 cases with esophageal cancer. Results: The median drinking
indices (DIs) were 546 and 1092 (p<0.01) in cases with positive FHIT expression and those with a diminished expression in
the esophageal epithelium, respectively. Furthermore, the incidences of intra-esophageal multiple cancer were 44% and 13%,
respectively (p<0.05). Regarding the expression in cancer lesions, the median DIs were 280 and 721 in positive and diminished
cases, respectively (p=0.081). Conclusion: A loss of FHIT expression is associated not only with alcohol-induced esophageal
carcinogenesis, but also with multicentric carcinogenesis.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 16821595</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Acid Anhydride Hydrolases - biosynthesis ; Aged ; Alcohol Drinking - adverse effects ; Alcohol Drinking - metabolism ; Biological and medical sciences ; Carcinoma, Squamous Cell - enzymology ; Carcinoma, Squamous Cell - etiology ; Carcinoma, Squamous Cell - pathology ; Epithelium - enzymology ; Esophageal Neoplasms - enzymology ; Esophageal Neoplasms - etiology ; Esophageal Neoplasms - pathology ; Esophagus ; Esophagus - enzymology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Middle Aged ; Neoplasm Proteins - biosynthesis ; Smoking - adverse effects ; Smoking - metabolism ; Tumors</subject><ispartof>Anticancer research, 2006-05, Vol.26 (3B), p.2243-2248</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17900478$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16821595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MORITA, Masaru</creatorcontrib><creatorcontrib>OYAMA, Tsunehiro</creatorcontrib><creatorcontrib>NAKATA, Shoji</creatorcontrib><creatorcontrib>ONO, Kenji</creatorcontrib><creatorcontrib>SUGAYA, Masakazu</creatorcontrib><creatorcontrib>URAMOTO, Hidetaka</creatorcontrib><creatorcontrib>YOSHIMATSU, Takashi</creatorcontrib><creatorcontrib>HANAGIRI, Takeshi</creatorcontrib><creatorcontrib>SUGIO, Kenji</creatorcontrib><creatorcontrib>YASUMOTO, Kosei</creatorcontrib><title>Expression of FHIT in Esophageal Epithelium and Carcinoma: Reference to Drinking, Smoking and Multicentric Carcinogenesis</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Both alcohol consumption and cigarette smoking are risk factors for esophageal cancer. The purpose of this study
was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in
multicentric carcinogenesis. Patients and Methods: The expression of FHIT was immunohistochemically examined in the squamous
cell carcinoma as well as in the normal esophageal epithelium of 55 cases with esophageal cancer. Results: The median drinking
indices (DIs) were 546 and 1092 (p<0.01) in cases with positive FHIT expression and those with a diminished expression in
the esophageal epithelium, respectively. Furthermore, the incidences of intra-esophageal multiple cancer were 44% and 13%,
respectively (p<0.05). Regarding the expression in cancer lesions, the median DIs were 280 and 721 in positive and diminished
cases, respectively (p=0.081). Conclusion: A loss of FHIT expression is associated not only with alcohol-induced esophageal
carcinogenesis, but also with multicentric carcinogenesis.</description><subject>Acid Anhydride Hydrolases - biosynthesis</subject><subject>Aged</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Epithelium - enzymology</subject><subject>Esophageal Neoplasms - enzymology</subject><subject>Esophageal Neoplasms - etiology</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagus</subject><subject>Esophagus - enzymology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Smoking - adverse effects</subject><subject>Smoking - metabolism</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MFOwzAMBuAIgdgYvALKBU5USpqlabnB6NikISQY58pN3TXQplXSCfb2FMbEyT58_mX7iIy5SnigpGDHZMxCyQLFmByRM-_fGYuiJBanZMSjOOQykWOyS786h96b1tK2pPPFck2Npalvuwo2CDVNO9NXWJttQ8EWdAZOG9s2cEtfsESHViPtW_rgjP0wdnNDX5v2p_nVT9u6Nxpt74w-jG7Qojf-nJyUUHu8-KsT8jZP17NFsHp-XM7uVkEVKtYHpcqVigUveMQkyAKnJQKwpIgjzXOeaJkrDmq4DIsijhOeh1IkDDnmWmqJYkIu97ndNm-wyDpnGnC77PCDAVz9AfAa6tKB1cb_O5UwNh1WmJDrvavMpvo0DjPfQF0PsSIDF0aZuM_CcCrEN3NSdIk</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>MORITA, Masaru</creator><creator>OYAMA, Tsunehiro</creator><creator>NAKATA, Shoji</creator><creator>ONO, Kenji</creator><creator>SUGAYA, Masakazu</creator><creator>URAMOTO, Hidetaka</creator><creator>YOSHIMATSU, Takashi</creator><creator>HANAGIRI, Takeshi</creator><creator>SUGIO, Kenji</creator><creator>YASUMOTO, Kosei</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20060501</creationdate><title>Expression of FHIT in Esophageal Epithelium and Carcinoma: Reference to Drinking, Smoking and Multicentric Carcinogenesis</title><author>MORITA, Masaru ; OYAMA, Tsunehiro ; NAKATA, Shoji ; ONO, Kenji ; SUGAYA, Masakazu ; URAMOTO, Hidetaka ; YOSHIMATSU, Takashi ; HANAGIRI, Takeshi ; SUGIO, Kenji ; YASUMOTO, Kosei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-f7b77831d1605a5de4feaa09d86c1b19c5b71a7669edd8891b25390e1ebc5c5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acid Anhydride Hydrolases - biosynthesis</topic><topic>Aged</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Epithelium - enzymology</topic><topic>Esophageal Neoplasms - enzymology</topic><topic>Esophageal Neoplasms - etiology</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagus</topic><topic>Esophagus - enzymology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Smoking - adverse effects</topic><topic>Smoking - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MORITA, Masaru</creatorcontrib><creatorcontrib>OYAMA, Tsunehiro</creatorcontrib><creatorcontrib>NAKATA, Shoji</creatorcontrib><creatorcontrib>ONO, Kenji</creatorcontrib><creatorcontrib>SUGAYA, Masakazu</creatorcontrib><creatorcontrib>URAMOTO, Hidetaka</creatorcontrib><creatorcontrib>YOSHIMATSU, Takashi</creatorcontrib><creatorcontrib>HANAGIRI, Takeshi</creatorcontrib><creatorcontrib>SUGIO, Kenji</creatorcontrib><creatorcontrib>YASUMOTO, Kosei</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORITA, Masaru</au><au>OYAMA, Tsunehiro</au><au>NAKATA, Shoji</au><au>ONO, Kenji</au><au>SUGAYA, Masakazu</au><au>URAMOTO, Hidetaka</au><au>YOSHIMATSU, Takashi</au><au>HANAGIRI, Takeshi</au><au>SUGIO, Kenji</au><au>YASUMOTO, Kosei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of FHIT in Esophageal Epithelium and Carcinoma: Reference to Drinking, Smoking and Multicentric Carcinogenesis</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>26</volume><issue>3B</issue><spage>2243</spage><epage>2248</epage><pages>2243-2248</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Both alcohol consumption and cigarette smoking are risk factors for esophageal cancer. The purpose of this study
was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in
multicentric carcinogenesis. Patients and Methods: The expression of FHIT was immunohistochemically examined in the squamous
cell carcinoma as well as in the normal esophageal epithelium of 55 cases with esophageal cancer. Results: The median drinking
indices (DIs) were 546 and 1092 (p<0.01) in cases with positive FHIT expression and those with a diminished expression in
the esophageal epithelium, respectively. Furthermore, the incidences of intra-esophageal multiple cancer were 44% and 13%,
respectively (p<0.05). Regarding the expression in cancer lesions, the median DIs were 280 and 721 in positive and diminished
cases, respectively (p=0.081). Conclusion: A loss of FHIT expression is associated not only with alcohol-induced esophageal
carcinogenesis, but also with multicentric carcinogenesis.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>16821595</pmid><tpages>6</tpages></addata></record> |
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| subjects | Acid Anhydride Hydrolases - biosynthesis Aged Alcohol Drinking - adverse effects Alcohol Drinking - metabolism Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - pathology Epithelium - enzymology Esophageal Neoplasms - enzymology Esophageal Neoplasms - etiology Esophageal Neoplasms - pathology Esophagus Esophagus - enzymology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Male Medical sciences Middle Aged Neoplasm Proteins - biosynthesis Smoking - adverse effects Smoking - metabolism Tumors |
| title | Expression of FHIT in Esophageal Epithelium and Carcinoma: Reference to Drinking, Smoking and Multicentric Carcinogenesis |
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