Expression of FHIT in Esophageal Epithelium and Carcinoma: Reference to Drinking, Smoking and Multicentric Carcinogenesis

Background: Both alcohol consumption and cigarette smoking are risk factors for esophageal cancer. The purpose of this study was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in multicentric carcinogenesis. Patients and Methods: Th...

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Veröffentlicht in:	Anticancer research 2006-05, Vol.26 (3B), p.2243-2248
Hauptverfasser:	MORITA, Masaru, OYAMA, Tsunehiro, NAKATA, Shoji, ONO, Kenji, SUGAYA, Masakazu, URAMOTO, Hidetaka, YOSHIMATSU, Takashi, HANAGIRI, Takeshi, SUGIO, Kenji, YASUMOTO, Kosei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases - biosynthesis Aged Alcohol Drinking - adverse effects Alcohol Drinking - metabolism Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - pathology Epithelium - enzymology Esophageal Neoplasms - enzymology Esophageal Neoplasms - etiology Esophageal Neoplasms - pathology Esophagus Esophagus - enzymology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Male Medical sciences Middle Aged Neoplasm Proteins - biosynthesis Smoking - adverse effects Smoking - metabolism Tumors
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Zusammenfassung:	Background: Both alcohol consumption and cigarette smoking are risk factors for esophageal cancer. The purpose of this study was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in multicentric carcinogenesis. Patients and Methods: The expression of FHIT was immunohistochemically examined in the squamous cell carcinoma as well as in the normal esophageal epithelium of 55 cases with esophageal cancer. Results: The median drinking indices (DIs) were 546 and 1092 (p
ISSN:	0250-7005 1791-7530