Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors

Novel 1-(2-acylhydrazinocarbonyl)cycloalkyl carboxamides were designed as peptidomimetic inhibitors of interleukin-1beta converting enzyme (ICE). A short synthesis was developed and moderately potent ICE inhibitors were identified (IC(50) values

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-08, Vol.16 (16), p.4233
Hauptverfasser:	Soper, David L, Sheville, Justin, O'Neil, Steven V, Wang, Yili, Laufersweiler, Michael C, Oppong, Kofi A, Wos, John A, Ellis, Christopher D, Fancher, Amy N, Lu, Wei, Suchanek, Maureen K, Wang, Richard L, De, Biswanath, Demuth, Jr, Thomas P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - pharmacology Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - chemical synthesis Caspase 8 Caspase Inhibitors Chemistry, Pharmaceutical - methods Cysteine Endopeptidases - metabolism Drug Industry - methods Drug Screening Assays, Antitumor Enzyme Inhibitors - pharmacology Humans Hydrazines - chemical synthesis Hydrazines - pharmacology Inhibitory Concentration 50 Models, Chemical
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Beschreibung
Zusammenfassung:	Novel 1-(2-acylhydrazinocarbonyl)cycloalkyl carboxamides were designed as peptidomimetic inhibitors of interleukin-1beta converting enzyme (ICE). A short synthesis was developed and moderately potent ICE inhibitors were identified (IC(50) values
ISSN:	0960-894X