The Role of Basic-Fibroblast Growth Factor (b-FGF) in Cyclosporine-induced Nephrotoxicity
Background: The effect of the b-fibroblast growth factor (b-FGF) on cyclosporine A (CsA)-induced nephrotoxicity in the rat kidney was investigated. Materials and Methods: The rats were divided into six groups: A (control), B (b-FGF-treated), C, D: (CsA-treated and sacrificed on days 14 or 21), E, F...
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| Veröffentlicht in: | In vivo (Athens) 2006-03, Vol.20 (2), p.265 |
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| creator | Efthimiadou, A Lambropoulou, M Pagonopoulou, O Vakalopoulos, I Papadopoulos, N Nikolettos, N |
| description | Background: The effect of the b-fibroblast growth factor (b-FGF) on cyclosporine A (CsA)-induced nephrotoxicity in the rat
kidney was investigated. Materials and Methods: The rats were divided into six groups: A (control), B (b-FGF-treated), C,
D: (CsA-treated and sacrificed on days 14 or 21), E, F (Cs A - and b-FGF- treated and sacrificed on days 14 or 21). The antibody
mouse anti-rat CD31 was used to evaluate the kidney vessels present in histological preparations. Results: The kidney vessels
in group B were increased in comparison with the control group (p |
| format | Article |
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kidney was investigated. Materials and Methods: The rats were divided into six groups: A (control), B (b-FGF-treated), C,
D: (CsA-treated and sacrificed on days 14 or 21), E, F (Cs A - and b-FGF- treated and sacrificed on days 14 or 21). The antibody
mouse anti-rat CD31 was used to evaluate the kidney vessels present in histological preparations. Results: The kidney vessels
in group B were increased in comparison with the control group (p<0.05). Reduction of kidney vessels in groups C and D (p<0.05)
in comparison with the controls was observed, while in groups E and F they were increased when compared to group C (p<0.05)
and D (p<0.05), respectively. Conclusion: The angiogenic role of b-FGF was confirmed in normal rats and a possible âprotectiveâ
role of b-FGF was shown in rat kidney with CsA-induced nephrotoxicity.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 16634529</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Animals ; Blood Vessels - drug effects ; Blood Vessels - pathology ; Cyclosporine - toxicity ; Drug Antagonism ; Drug Therapy, Combination ; Fibroblast Growth Factor 2 - metabolism ; Fibroblast Growth Factor 2 - pharmacology ; Immunosuppressive Agents - toxicity ; Injections, Intramuscular ; Kidney - blood supply ; Kidney - drug effects ; Kidney Diseases - chemically induced ; Kidney Diseases - metabolism ; Kidney Diseases - pathology ; Male ; Neovascularization, Physiologic - drug effects ; Neovascularization, Physiologic - physiology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>In vivo (Athens), 2006-03, Vol.20 (2), p.265</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16634529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Efthimiadou, A</creatorcontrib><creatorcontrib>Lambropoulou, M</creatorcontrib><creatorcontrib>Pagonopoulou, O</creatorcontrib><creatorcontrib>Vakalopoulos, I</creatorcontrib><creatorcontrib>Papadopoulos, N</creatorcontrib><creatorcontrib>Nikolettos, N</creatorcontrib><title>The Role of Basic-Fibroblast Growth Factor (b-FGF) in Cyclosporine-induced Nephrotoxicity</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Background: The effect of the b-fibroblast growth factor (b-FGF) on cyclosporine A (CsA)-induced nephrotoxicity in the rat
kidney was investigated. Materials and Methods: The rats were divided into six groups: A (control), B (b-FGF-treated), C,
D: (CsA-treated and sacrificed on days 14 or 21), E, F (Cs A - and b-FGF- treated and sacrificed on days 14 or 21). The antibody
mouse anti-rat CD31 was used to evaluate the kidney vessels present in histological preparations. Results: The kidney vessels
in group B were increased in comparison with the control group (p<0.05). Reduction of kidney vessels in groups C and D (p<0.05)
in comparison with the controls was observed, while in groups E and F they were increased when compared to group C (p<0.05)
and D (p<0.05), respectively. Conclusion: The angiogenic role of b-FGF was confirmed in normal rats and a possible âprotectiveâ
role of b-FGF was shown in rat kidney with CsA-induced nephrotoxicity.</description><subject>Animals</subject><subject>Blood Vessels - drug effects</subject><subject>Blood Vessels - pathology</subject><subject>Cyclosporine - toxicity</subject><subject>Drug Antagonism</subject><subject>Drug Therapy, Combination</subject><subject>Fibroblast Growth Factor 2 - metabolism</subject><subject>Fibroblast Growth Factor 2 - pharmacology</subject><subject>Immunosuppressive Agents - toxicity</subject><subject>Injections, Intramuscular</subject><subject>Kidney - blood supply</subject><subject>Kidney - drug effects</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - pathology</subject><subject>Male</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Neovascularization, Physiologic - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1z01LwzAAxvEgipvTryA5eNBDIC9Nkx512CkMBZmgp5JXG-mWknSb-_YWpqf_5ccDzwmYElERJHhRnYIpplwiycnHBFzk_I1xKTCm52BCypIVnFZT8LlqHXyLnYPRwweVg0F10CnqTuUBLlLcDy2slRligrca1Yv6DoYNnB9MF3MfU9g4FDZ2a5yFL65vUxziTzBhOFyCM6-67K7-OgPv9eNq_oSWr4vn-f0StaSUA2JWi8pJwqUnHBeUCOm4cIZzz61WYwutvKCMUGmttm7U2gjvscWWs4LNwPVxt9_qtbNNn8JapUPz_3EEN0fQhq92H5Jr8lp13chZE3YUN7ShJWe_BkRbYA</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Efthimiadou, A</creator><creator>Lambropoulou, M</creator><creator>Pagonopoulou, O</creator><creator>Vakalopoulos, I</creator><creator>Papadopoulos, N</creator><creator>Nikolettos, N</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20060301</creationdate><title>The Role of Basic-Fibroblast Growth Factor (b-FGF) in Cyclosporine-induced Nephrotoxicity</title><author>Efthimiadou, A ; Lambropoulou, M ; Pagonopoulou, O ; Vakalopoulos, I ; Papadopoulos, N ; Nikolettos, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h168t-3db79e8158f15042178e57ec55f5dbac554baf723128ddbde79ebc7ff0d0d5343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Blood Vessels - drug effects</topic><topic>Blood Vessels - pathology</topic><topic>Cyclosporine - toxicity</topic><topic>Drug Antagonism</topic><topic>Drug Therapy, Combination</topic><topic>Fibroblast Growth Factor 2 - metabolism</topic><topic>Fibroblast Growth Factor 2 - pharmacology</topic><topic>Immunosuppressive Agents - toxicity</topic><topic>Injections, Intramuscular</topic><topic>Kidney - blood supply</topic><topic>Kidney - drug effects</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - pathology</topic><topic>Male</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Neovascularization, Physiologic - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Efthimiadou, A</creatorcontrib><creatorcontrib>Lambropoulou, M</creatorcontrib><creatorcontrib>Pagonopoulou, O</creatorcontrib><creatorcontrib>Vakalopoulos, I</creatorcontrib><creatorcontrib>Papadopoulos, N</creatorcontrib><creatorcontrib>Nikolettos, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Efthimiadou, A</au><au>Lambropoulou, M</au><au>Pagonopoulou, O</au><au>Vakalopoulos, I</au><au>Papadopoulos, N</au><au>Nikolettos, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Basic-Fibroblast Growth Factor (b-FGF) in Cyclosporine-induced Nephrotoxicity</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>20</volume><issue>2</issue><spage>265</spage><pages>265-</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>Background: The effect of the b-fibroblast growth factor (b-FGF) on cyclosporine A (CsA)-induced nephrotoxicity in the rat
kidney was investigated. Materials and Methods: The rats were divided into six groups: A (control), B (b-FGF-treated), C,
D: (CsA-treated and sacrificed on days 14 or 21), E, F (Cs A - and b-FGF- treated and sacrificed on days 14 or 21). The antibody
mouse anti-rat CD31 was used to evaluate the kidney vessels present in histological preparations. Results: The kidney vessels
in group B were increased in comparison with the control group (p<0.05). Reduction of kidney vessels in groups C and D (p<0.05)
in comparison with the controls was observed, while in groups E and F they were increased when compared to group C (p<0.05)
and D (p<0.05), respectively. Conclusion: The angiogenic role of b-FGF was confirmed in normal rats and a possible âprotectiveâ
role of b-FGF was shown in rat kidney with CsA-induced nephrotoxicity.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>16634529</pmid></addata></record> |
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| ispartof | In vivo (Athens), 2006-03, Vol.20 (2), p.265 |
| issn | 0258-851X 1791-7549 |
| language | eng |
| recordid | cdi_pubmed_primary_16634529 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Blood Vessels - drug effects Blood Vessels - pathology Cyclosporine - toxicity Drug Antagonism Drug Therapy, Combination Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factor 2 - pharmacology Immunosuppressive Agents - toxicity Injections, Intramuscular Kidney - blood supply Kidney - drug effects Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Male Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Rats Rats, Sprague-Dawley |
| title | The Role of Basic-Fibroblast Growth Factor (b-FGF) in Cyclosporine-induced Nephrotoxicity |
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