The Role of Basic-Fibroblast Growth Factor (b-FGF) in Cyclosporine-induced Nephrotoxicity

Background: The effect of the b-fibroblast growth factor (b-FGF) on cyclosporine A (CsA)-induced nephrotoxicity in the rat kidney was investigated. Materials and Methods: The rats were divided into six groups: A (control), B (b-FGF-treated), C, D: (CsA-treated and sacrificed on days 14 or 21), E, F...

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Veröffentlicht in:	In vivo (Athens) 2006-03, Vol.20 (2), p.265
Hauptverfasser:	Efthimiadou, A, Lambropoulou, M, Pagonopoulou, O, Vakalopoulos, I, Papadopoulos, N, Nikolettos, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Vessels - drug effects Blood Vessels - pathology Cyclosporine - toxicity Drug Antagonism Drug Therapy, Combination Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factor 2 - pharmacology Immunosuppressive Agents - toxicity Injections, Intramuscular Kidney - blood supply Kidney - drug effects Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Male Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Rats Rats, Sprague-Dawley
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Zusammenfassung:	Background: The effect of the b-fibroblast growth factor (b-FGF) on cyclosporine A (CsA)-induced nephrotoxicity in the rat kidney was investigated. Materials and Methods: The rats were divided into six groups: A (control), B (b-FGF-treated), C, D: (CsA-treated and sacrificed on days 14 or 21), E, F (Cs A - and b-FGF- treated and sacrificed on days 14 or 21). The antibody mouse anti-rat CD31 was used to evaluate the kidney vessels present in histological preparations. Results: The kidney vessels in group B were increased in comparison with the control group (p
ISSN:	0258-851X 1791-7549