Vagina cancer in a young woman exposed to diethylstilbestrol: case report and literature review

We analyzed a 20 year-old patient case exposed in utero to diethylstilbestrol, as probably predisposed factor in vaginal cancer. The histopathological report of the incisional biopsy was clear cell vaginal adenocarcinoma, stage III, widespread to the pelvic wall, with metastasis to regional lymph no...

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Veröffentlicht in:	Ginecologia y obstetricia de Mexico 2005-12, Vol.73 (12), p.666
Hauptverfasser:	Novoa Vargas, Arturo, Grados García, Conrado, Bustillos de Cima, Roberto, Malagón Millán, Berenice
Format:	Artikel
Sprache:	spa
Schlagworte:	Adenocarcinoma, Clear Cell - chemically induced Adenocarcinoma, Clear Cell - diagnostic imaging Adenocarcinoma, Clear Cell - drug therapy Adenocarcinoma, Clear Cell - pathology Adenocarcinoma, Clear Cell - surgery Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biopsy Chemotherapy, Adjuvant Diethylstilbestrol - adverse effects Female Follow-Up Studies Humans Hysterectomy Lymphatic Metastasis Pregnancy Prenatal Exposure Delayed Effects Prognosis Radiography, Abdominal Time Factors Tomography, X-Ray Computed Vagina - pathology Vaginal Neoplasms - chemically induced Vaginal Neoplasms - diagnostic imaging Vaginal Neoplasms - drug therapy Vaginal Neoplasms - pathology Vaginal Neoplasms - surgery
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Zusammenfassung:	We analyzed a 20 year-old patient case exposed in utero to diethylstilbestrol, as probably predisposed factor in vaginal cancer. The histopathological report of the incisional biopsy was clear cell vaginal adenocarcinoma, stage III, widespread to the pelvic wall, with metastasis to regional lymph nodes, and lack of distant metastasis. We decided surgical management: protocolized laparotomy, peritoneal washing, retroperitoneal node biopsies and a radical hysterectomy, Piver III, with two thirds parts of vagina. By poor prognosis we decided to offer an adjuvant management, with systemic chemotherapy.
ISSN:	0300-9041