Blood pressure-depressing activity of a peptide derived from silkworm fibroin in spontaneously hypertensive rats

Peptides showing inhibitory activity against the angiotensin I-converting enzyme (ACE) were investigated from the fibroin fraction of discarded silk fabric. Fibroin, which was hydrolyzed with alcalase after partial hydrolysis with hot aqueous 40% CaC12, released two major active peptides showing ACE...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2006, Vol.70 (2), p.517-520
Hauptverfasser:	Igarashi, K.(Yamagata Univ., Tsuruoka (Japan). Faculty of Agriculture), Yoshioka, K, Mizutani, K, Miyakoshi, M, Murakami, T, Akizawa, T
Format:	Artikel
Sprache:	eng
Schlagworte:	ANGIOTENSIN angiotensin I-converting enzyme ANGIOTENSINA ANGIOTENSINE Animals APROVECHAMIENTO DE DESECHOS Biological and medical sciences blood pressure Blood Pressure - drug effects Bombyx mori CARDIOVASCULAR AGENTS Chromatography, High Pressure Liquid fibroin Fibroins - pharmacology Fundamental and applied biological sciences. Psychology HIPERTENSION HYPERTENSION MEDICAMENTOS CARDIOVASCULARES MODIFICATEUR CARDIOVASCULAIRE PEPTIDE Peptide Fragments - pharmacology PEPTIDES PEPTIDOS RAT RATA RATS Rats, Inbred SHR SEDA SILK SOIE spontaneously hypertensive rat (SHR) UTILISATION DES DECHETS WASTE UTILIZATION
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Zusammenfassung:	Peptides showing inhibitory activity against the angiotensin I-converting enzyme (ACE) were investigated from the fibroin fraction of discarded silk fabric. Fibroin, which was hydrolyzed with alcalase after partial hydrolysis with hot aqueous 40% CaC12, released two major active peptides showing ACE-inhibitory activity. The two peptides were identified as glycylvalyl-glycyl-tyrosine (GVGY) and glycyl-valyl-glycylalanyl-glycyl-tyrosine- (GVGAGY) by analyses with a protein sequencer and LC/MS/MS. GVGY, whose ACE-inhibitory activity has not previously been reported, showed a blood pressure-depressing effect on spontaneously hypertensive rat (SHR).
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.70.517