Pneumatosis Cystoides Intestinalis after αGlucosidase Inhibitor Treatment in a Patient with Interstitial Pneumonitis

A 56yearold woman was admitted to our hospital for treatment of nonspecific interstitial pneumonitis (NSIP). The patient started prednisone treatment, but one month later treatment with voglibose, an αglucosidase inhibitor (αGI), was started because of prednisoneinduced diabetes mellitus. One week later, a massive volume of free air below the diaphragm was detected by a chest Xray examination. An abdominal CT examination demonstrated pneumatosis coli and the patient was diagnosed with pneumatosis cystoides intestinalis (PCI). Voglibose was discontinued and parenteral nutrition and oxygen inhalation were initiated. Radiographic findings of PCI disappeared within 7 days. We encountered a rare case of PCI, that was associated with αGI treatment.