Drug combinations: statins and niacin

Combination of statins with niacin appears to be an attractive association, in the presence of mixed dyslipidemia with low HDL-c levels, when monotherapy is insufficient to achieve target lipid levels. Clinical benefits were observed by the combination of statins with niacin in the FATS, HATS and AR...

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Veröffentlicht in:	Arquivos brasileiros de cardiologia 2005-10, Vol.85 Suppl 5, p.36
1. Verfasser:	Borges, Jairo Lins
Format:	Artikel
Sprache:	por
Schlagworte:	Age Distribution Atherosclerosis - drug therapy Atherosclerosis - metabolism Atorvastatin Calcium Cholesterol, HDL - blood Cholesterol, LDL - blood Drug Interactions Drug Therapy, Combination Dyslipidemias - drug therapy Dyslipidemias - metabolism Female Heptanoic Acids - adverse effects Heptanoic Acids - metabolism Heptanoic Acids - therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Male Niacin - adverse effects Niacin - metabolism Niacin - therapeutic use Pyrroles - adverse effects Pyrroles - metabolism Pyrroles - therapeutic use Sex Factors Simvastatin - adverse effects Simvastatin - metabolism Simvastatin - therapeutic use
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Zusammenfassung:	Combination of statins with niacin appears to be an attractive association, in the presence of mixed dyslipidemia with low HDL-c levels, when monotherapy is insufficient to achieve target lipid levels. Clinical benefits were observed by the combination of statins with niacin in the FATS, HATS and ARBITER 2 trials, showing attenuation of atherosclerosis development and/or reduction in coronary events following favorable lipid changes. In general, this combination can be well-tolerated. Recommendations for appropriate monitoring of liver and muscle enzymes are important to reduce the rate of side effects. In addition, careful titration of each drug is recommended.
ISSN:	0066-782X