Cytotoxic lignans from the stems of Helicteres hirsuta collected in indonesia

Cytotoxicity‐guided fractionation of the stems of Helicteres hirsuta, of Indonesian origin, led to the isolation and identification of six lignans, namely, (±)‐pinoresinol, (±)‐medioresinol, (±)‐syringaresinol, (−)‐boehmenan, (−)‐boehmenan H and (±)‐trans‐dihydrodiconiferyl alcohol. Of these isolate...

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Veröffentlicht in:	Phytotherapy research 2006, Vol.20 (1), p.62-65
Hauptverfasser:	Chin, Y.W, Jones, W.P, Rachman, I, Riswan, S, Kardono, L.B.S, Chai, H.B, Farnsworth, N.R, Cordell, G.A, Swanson, S.M, Cassady, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences cancer cell lines Cell Line Cell Line, Tumor Chromatography, High Pressure Liquid - methods cytotoxic constituents General pharmacology Helicteres hirsuta Humans Indonesia lignans Lignans - chemistry Lignans - isolation & purification Lignans - toxicity Mass Spectrometry - methods Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Stems - chemistry Sterculiaceae - chemistry Toxicity Tests
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Zusammenfassung:	Cytotoxicity‐guided fractionation of the stems of Helicteres hirsuta, of Indonesian origin, led to the isolation and identification of six lignans, namely, (±)‐pinoresinol, (±)‐medioresinol, (±)‐syringaresinol, (−)‐boehmenan, (−)‐boehmenan H and (±)‐trans‐dihydrodiconiferyl alcohol. Of these isolates, (±)‐pinoresinol exhibited potent cytotoxic effects when evaluated against a small panel of cancer cell lines. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.1806