Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus

Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus

Abstract Nineteen compounds isolated from RANUNCULUS SIEBOLDII and RANUNCULUS SCELERATUS were tested for inhibitory effects on hepatitis B virus (HBV) and HERPES SIMPLEX virus type-1 (HSV-1). The results showed that apigenin 4′-O-α-rhamnopyranoside (1), apigenin 7-O-β-glucopyranosyl-4′-O-α-rhamnopyr...

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Veröffentlicht in:Planta medica 2005-12, Vol.71 (12), p.1128-1133
Hauptverfasser: Li, H, Zhou, C.X, Pan, Y, Gao, X, Wu, X, Bai, H, Zhou, L, Chen, Z, Zhang, S, Shi, S
Format: Artikel
Sprache:eng
Schlagworte:
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
antiviral properties
Biological and medical sciences
Cell Line
DNA, Mitochondrial
flavones
Flavonoids - chemistry
Flavonoids - pharmacology
General pharmacology
glycosides
Hepatitis B virus
herbaceous plants
Herpesvirus 1, Human - drug effects
Herpesvirus 1, Human - physiology
Human herpesvirus 1
Humans
Inhibitory Concentration 50
Medical sciences
medicinal plants
molecular sequence data
Molecular Structure
nucleotide sequences
Original Paper
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
Phytotherapy
plant extracts
Ranunculus
Ranunculus - chemistry
Ranunculus sceleratus
Virus Replication - drug effects
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Zusammenfassung:Abstract Nineteen compounds isolated from RANUNCULUS SIEBOLDII and RANUNCULUS SCELERATUS were tested for inhibitory effects on hepatitis B virus (HBV) and HERPES SIMPLEX virus type-1 (HSV-1). The results showed that apigenin 4′-O-α-rhamnopyranoside (1), apigenin 7-O-β-glucopyranosyl-4′-O-α-rhamnopyranoside (4), tricin 7-O-β-glucopyranoside (5), tricin (12), and isoscopoletin (18) possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde (19) exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new antiviral agents.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2005-873169