Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2005-11, Vol.49 (11), p.4721-4732
Hauptverfasser:	DORR, Patrick, WESTBY, Mike, WEBSTER, Rob, ARMOUR, Duncan, PRICE, David, STAMMEN, Blanda, WOOD, Anthony, PERROS, Manos, DOBBS, Susan, GRIFFIN, Paul, IRVINE, Becky, MACARTNEY, Malcolm, MORI, Julie, RICKETT, Graham, SMITH-BURCHNELL, Caroline, NAPIER, Carolyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - drug therapy Animals Anti-HIV Agents Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Biological and medical sciences Biological Availability CCR5 Receptor Antagonists Cyclohexanes Cyclohexanes - pharmacokinetics Cyclohexanes - pharmacology Dogs Drug Resistance, Viral Drug Therapy, Combination HeLa Cells HIV-1 HIV-1 - drug effects Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Membrane Fusion - drug effects Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptors, CCR5 - metabolism Triazoles Triazoles - pharmacokinetics Triazoles - pharmacology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.49.11.4721-4732.2005