Biosynthesis of glyantrypine by Aspergillus clavatus

The biosynthesis of glyantrypine from radiolabelled amino acid precursors has been shown experimentally to involve anthranilic acid, tryptophan and glycine. Low values for percentage incorporation of radiolabel into glyantrypine were partly influenced by a complex array of other novel alkaloids show...

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Veröffentlicht in:	FEMS microbiology letters 1992-05, Vol.92 (3), p.229-233
Hauptverfasser:	Penn, Julia, Purcell, Marianne, Mantle, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloid Alkaloids - metabolism Amino Acids - metabolism Anthranilic acid Aspergillus - growth & development Aspergillus - metabolism Aspergillus clavatus Glyantrypine Glycine - metabolism Life Sciences & Biomedicine Microbiology ortho-Aminobenzoates - metabolism Quinazolines - metabolism Science & Technology Tryptophan - analogs & derivatives Tryptophan - metabolism
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Zusammenfassung:	The biosynthesis of glyantrypine from radiolabelled amino acid precursors has been shown experimentally to involve anthranilic acid, tryptophan and glycine. Low values for percentage incorporation of radiolabel into glyantrypine were partly influenced by a complex array of other novel alkaloids shown by the radiolabelling experiments to be related to glyantrypine. Interpretation of radiolabel incorporation from [ 14C-carboxyl]-anthranilic acid into microbial metabolites seen to contain an anthranilyl moiety in various biosynthetic arrangements is discussed. The possibility of diversion of anthranilic acid from the kynurenine pathway to glyantrypine biosynthesis is recognised.
ISSN:	0378-1097 1574-6968
DOI:	10.1016/0378-1097(92)90714-Y