A study on ceftriaxone-induced lipid peroxidation using 4-hydroxy-2-nonenal as model marker

4-Hydroxy-2-nonenal, an indicator of lipid peroxidation process. was used as model marker to explore ceftriaxone-induced lipid peroxidation in goat liver homogenate. Ceftriaxone was found to induce lipid peroxidation significantly. It was further found that ascorbic acid could significantly arrest c...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2005-03, Vol.62 (2), p.141
Hauptverfasser:	Chakraborty, Santanu, Bhuti, Pritesh Dev, Ray, Supratim, Sengupta, Chandana, Roy, Kunal
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - metabolism Analysis of Variance Animals Anti-Bacterial Agents - toxicity Antioxidants - pharmacology Ascorbic Acid - pharmacology Biomarkers - metabolism Ceftriaxone - toxicity Glutathione - metabolism Goats Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Malondialdehyde - metabolism Nitric Oxide - metabolism Reproducibility of Results Time Factors
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Zusammenfassung:	4-Hydroxy-2-nonenal, an indicator of lipid peroxidation process. was used as model marker to explore ceftriaxone-induced lipid peroxidation in goat liver homogenate. Ceftriaxone was found to induce lipid peroxidation significantly. It was further found that ascorbic acid could significantly arrest ceftriaxone-induced lipid peroxidation. The results corroborate the earlier findings with malondialdehyde as model marker.
ISSN:	0001-6837