l-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease
We investigated the effects of oral l-arginine on endothelial function, intravascular oxidative stress, and circulating inflammatory markers in patients with stable coronary artery disease (CAD). Thirty-one stable CAD patients were randomly assigned to oral l-arginine (10 g) or vitamin C (500 mg, an...
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Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2005-12, Vol.24 (6), p.988-997 |
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Sprache: | eng |
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Zusammenfassung: | We investigated the effects of oral
l-arginine on endothelial function, intravascular oxidative stress, and circulating inflammatory markers in patients with stable coronary artery disease (CAD).
Thirty-one stable CAD patients were randomly assigned to oral
l-arginine (10
g) or vitamin C (500
mg, an antioxidant, as active control) daily for 4 weeks, with crossover to the alternate therapy after 2 weeks off therapy, in this study. Brachial artery endothelial function studies were performed and serum concentrations of lipids and inflammatory markers were measured at baseline, at the end of each 4-week treatment period and at the 2-week wash-out period. Susceptibility of low-density lipoprotein (LDL) particles to oxidation, a marker of oxidative stress, was determined in 11 patients at random before and after 4-week treatment of oral
l-arginine.
We demonstrates that consumption of either
l-arginine or vitamin C significantly increased brachial artery flow-mediated dilatation (mean diameter change from baseline of 4.87%,
P
<
0.0001
and of 3.17%,
P
=
0.0003
, respectively). Neither oral
l-arginine nor vitamin C affected lipid profiles and circulating levels of inflammatory markers. However, in the 11 patients whose LDL susceptibility to oxidation was determined, lag time significantly increased by 27.1% (
P
=
0.045
) after consumption of
l-arginine for 4 weeks.
Oral
l-arginine supplement improved endothelial function and reduced LDL oxidation in stable CAD patients. |
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ISSN: | 0261-5614 1532-1983 |
DOI: | 10.1016/j.clnu.2005.07.003 |