Relationship Between HbA1c Level and Peripheral Arterial Disease

Relationship Between HbA 1c Level and Peripheral Arterial Disease Paul Muntner , PHD 1 2 , Rachel P. Wildman , PHD 1 , Kristi Reynolds , PHD 1 , Karen B. DeSalvo , MD 1 2 , Jing Chen , MD 2 and Vivian Fonseca , MD 2 1 Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 2 Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana Address correspondence and reprint requests to Paul Muntner, Department of Epidemiology, Tulane University SPHTM, 1430 Tulane Ave., SL-18 New Orleans, LA 70112. E-mail: pmuntner{at}tulane.edu Abstract OBJECTIVE —Homeostatic glucose control may play an important role in the development of peripheral arterial disease among individuals without diabetes. We sought to evaluate the association of HbA 1c (A1C) with peripheral arterial disease in a representative sample of the U.S. population with and without diabetes. RESEARCH DESIGN AND METHODS —A cross-sectional study was conducted among 4,526 National Health and Nutrition Examination Survey 1999–2002 participants ≥40 years of age. Peripheral arterial disease was defined as an ankle-brachial index