Certain Site-Directed, Nonenzymatically Active Mutants of the Haemophilus influenzae P4 Lipoprotein Are Able To Elicit Bactericidal Antibodies

The Haemophilus influenzae P4 lipoprotein (hel) is a potential component of a nontypeable H. influenzae otitis media vaccine. Since P4 is known to be an enzyme, nonenzymatically active forms of recombinant P4 are required. After site-directed mutagenesis of the hel gene, three of the mutated protein...

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Veröffentlicht in:	Infection and Immunity 2005-07, Vol.73 (7), p.4454-4457
Hauptverfasser:	Green, Bruce A, Baranyi, Elizabeth, Reilly, Thomas J, Smith, Arnold L, Zlotnick, Gary W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bacterial - immunology Bacterial Proteins - immunology Bacteriology Biological and medical sciences Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Haemophilus influenzae - immunology Humans Lipoproteins - immunology Microbial Immunity and Vaccines Microbiology Miscellaneous Mutation Structure-Activity Relationship
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Zusammenfassung:	The Haemophilus influenzae P4 lipoprotein (hel) is a potential component of a nontypeable H. influenzae otitis media vaccine. Since P4 is known to be an enzyme, nonenzymatically active forms of recombinant P4 are required. After site-directed mutagenesis of the hel gene, three of the mutated proteins were shown to be vaccine candidates.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.73.7.4454-4457.2005