Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos

Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-beta-D-g...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-05, Vol.68 (5), p.766-768
Hauptverfasser:	Kim, G.S, Kim, H.T, Seong, J.D, Oh, S.R, Lee, C.O, Bang, J.K, Seong, N.S, Song, K.S
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology aspaoligonins Asparagus (Asparagaceae) Asparagus oligoclonos Asparagus Plant - chemistry asparanin Biological and medical sciences chemical structure cultured cells cytotoxicity General pharmacology Humans Inhibitory Concentration 50 Korea Medical sciences medicinal plants Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plants, Medicinal - chemistry Rhizome - chemistry rhizomes Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology spectral analysis Spirostans - chemistry Spirostans - isolation & purification Spirostans - pharmacology Stereoisomerism steroid saponins Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S)-5beta-spirostan-3beta,17alpha-diol 3-O-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranoside and (25S)-5beta-spirostan-3beta,17alpha-diol 3-O-alpha-L-rhamnopyanosyl (1-->4)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranoside, respectively, by spectrometric analyses including HRFABMS and 2D NMR. Compounds 1-3 were cytotoxic against five human tumor cell lines with IC50 values of 2.05-2.84 microg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np040128k