Macrophage Migration Inhibitory Factor Reduces the Growth of Virulent Mycobacterium tuberculosis in Human Macrophages

Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages i...

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Veröffentlicht in:	Infection and Immunity 2005-06, Vol.73 (6), p.3783-3786
Hauptverfasser:	Oddo, Mauro, Calandra, Thierry, Bucala, Richard, Meylan, Pascal R. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Host Response and Inflammation Humans Macrophage Migration-Inhibitory Factors - physiology Macrophages - immunology Macrophages - microbiology Microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - immunology Virulence
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Beschreibung
Zusammenfassung:	Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.73.6.3783-3786.2005