Inhibition of Branching Morphogenesis of Mouse Fetal Submandibular Gland by Sodium Fluoride - Protection by Epidermal Growth Factor

As an initial step to study the effect of sodium fluoride on the oral environment, we investigated how sodium fluoride (NaF) affects the branching morphogenesis of fetal mouse submandibular gland (SMG). When mouse SMG was prepared from the embryo at 13 days post prenatal stage and cultured, gradual...

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Veröffentlicht in:	In vivo (Athens) 2005-03, Vol.19 (2), p.327
Hauptverfasser:	Naka, Takahiro, Maruyama, Shichiro, Nagao, Takahide, Takayama, Fumitoshi, Maki, Jun, Yasui, Toshikazu, Sakagami, Hiroshi, Ohkawa, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dihydrotestosterone - pharmacology Dose-Response Relationship, Drug Epidermal Growth Factor - pharmacology Mice Mice, Inbred ICR Morphogenesis - drug effects Organ Culture Techniques Sodium Fluoride - toxicity Somatomedins - pharmacology Submandibular Gland - drug effects Submandibular Gland - embryology
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Zusammenfassung:	As an initial step to study the effect of sodium fluoride on the oral environment, we investigated how sodium fluoride (NaF) affects the branching morphogenesis of fetal mouse submandibular gland (SMG). When mouse SMG was prepared from the embryo at 13 days post prenatal stage and cultured, gradual development of branching morphogenesis was observed. Addition of NaF affected this morphological change in bimodal fashions. At a lower concentration of NaF (
ISSN:	0258-851X 1791-7549