3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells
The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistan...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2005-03, Vol.15 (6), p.1633 |
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| container_issue | 6 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Dimmock, Jonathan R Das, Umashankar Gul, H Inci Kawase, Masami Sakagami, Hiroshi Baráth, Zoltán Ocsovsky, Imre Molnár, Joseph |
| description | The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistance. |
| doi_str_mv | 10.1016/j.bmcl.2005.01.054 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1633 |
| issn | 0960-894X |
| language | eng |
| recordid | cdi_pubmed_primary_15745812 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Colonic Neoplasms - drug therapy Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Humans Ketones - chemical synthesis Ketones - chemistry Ketones - pharmacology Leukemia L5178 - drug therapy Molecular Structure |
| title | 3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells |
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