3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells

The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistan...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-03, Vol.15 (6), p.1633
Hauptverfasser:	Dimmock, Jonathan R, Das, Umashankar, Gul, H Inci, Kawase, Masami, Sakagami, Hiroshi, Baráth, Zoltán, Ocsovsky, Imre, Molnár, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Colonic Neoplasms - drug therapy Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Humans Ketones - chemical synthesis Ketones - chemistry Ketones - pharmacology Leukemia L5178 - drug therapy Molecular Structure
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Beschreibung
Zusammenfassung:	The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistance.
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2005.01.054