Bioactive constituents from Boswellia papyrifera
Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxys...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2005-02, Vol.68 (2), p.189-193 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Atta-ur-Rahman Naz, H Fadimatou Makhmoor, T Yasin, A Fatima, N Ngounou, F.N Kimbu, S.F Sondengam, B.L Choudhary, M.I |
| description | Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), beta-elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10). The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities. |
| doi_str_mv | 10.1021/np040142x |
| format | Article |
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The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np040142x</identifier><identifier>PMID: 15730241</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Biological and medical sciences ; Boswellia ; Boswellia - chemistry ; Boswellia papyrifera ; Cameroon ; chemical structure ; enzyme inhibitors ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - isolation & purification ; Enzyme Inhibitors - pharmacology ; General pharmacology ; glycosides ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Inhibitory Concentration 50 ; Medical sciences ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phosphodiesterase I ; phytochemicals ; plant extracts ; Plants, Medicinal - chemistry ; spectral analysis ; stereochemistry ; stilbenes ; Stilbenes - chemistry ; Stilbenes - isolation & purification ; Stilbenes - pharmacology ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; triterpenoids ; xanthine oxidase</subject><ispartof>Journal of natural products (Washington, D.C.), 2005-02, Vol.68 (2), p.189-193</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16614085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15730241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atta-ur-Rahman</creatorcontrib><creatorcontrib>Naz, H</creatorcontrib><creatorcontrib>Fadimatou</creatorcontrib><creatorcontrib>Makhmoor, T</creatorcontrib><creatorcontrib>Yasin, A</creatorcontrib><creatorcontrib>Fatima, N</creatorcontrib><creatorcontrib>Ngounou, F.N</creatorcontrib><creatorcontrib>Kimbu, S.F</creatorcontrib><creatorcontrib>Sondengam, B.L</creatorcontrib><creatorcontrib>Choudhary, M.I</creatorcontrib><title>Bioactive constituents from Boswellia papyrifera</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), beta-elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10). The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.</description><subject>Biological and medical sciences</subject><subject>Boswellia</subject><subject>Boswellia - chemistry</subject><subject>Boswellia papyrifera</subject><subject>Cameroon</subject><subject>chemical structure</subject><subject>enzyme inhibitors</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - isolation & purification</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>General pharmacology</subject><subject>glycosides</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Inhibitory Concentration 50</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phosphodiesterase I</subject><subject>phytochemicals</subject><subject>plant extracts</subject><subject>Plants, Medicinal - chemistry</subject><subject>spectral analysis</subject><subject>stereochemistry</subject><subject>stilbenes</subject><subject>Stilbenes - chemistry</subject><subject>Stilbenes - isolation & purification</subject><subject>Stilbenes - pharmacology</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>triterpenoids</subject><subject>xanthine oxidase</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFzs1Kw0AUBeBBFFurC19As3EZvXf-MlmaYlUoKKRdh0kyI6NpEmaitm9voFVXZ3E-DoeQS4RbBIp3bQ8ckNPtEZmioBBLoOKYTAEli5mSfELOQngHAAapOCUTFAkDynFKIHOdrgb3ZaKqa8Pghk_TDiGyvttEWRe-TdM4HfW633lnjdfn5MTqJpiLQ87IevGwmj_Fy5fH5_n9MrYMcIitAMlrw7BOaCIMokqNQmNRKBSa1XVVc8kEE7VipkrLUiUWqpRTW1pNkbIZudrv9p_lxtRF791G-13xe30ENwegQ6Ub63VbufDvpEQOSowu3jsXBrP967X_KGTCElGsXvMiW-Uyw2RR5KO_3nuru0K_-XFznVNABpCmSijFfgAytWmK</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Atta-ur-Rahman</creator><creator>Naz, H</creator><creator>Fadimatou</creator><creator>Makhmoor, T</creator><creator>Yasin, A</creator><creator>Fatima, N</creator><creator>Ngounou, F.N</creator><creator>Kimbu, S.F</creator><creator>Sondengam, B.L</creator><creator>Choudhary, M.I</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20050201</creationdate><title>Bioactive constituents from Boswellia papyrifera</title><author>Atta-ur-Rahman ; Naz, H ; Fadimatou ; Makhmoor, T ; Yasin, A ; Fatima, N ; Ngounou, F.N ; Kimbu, S.F ; Sondengam, B.L ; Choudhary, M.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f301t-f5064de31d7275e1189e81ef15815a3ddcd463535d83ec9bb87f0c942fbfa2123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Boswellia</topic><topic>Boswellia - chemistry</topic><topic>Boswellia papyrifera</topic><topic>Cameroon</topic><topic>chemical structure</topic><topic>enzyme inhibitors</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - isolation & purification</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>General pharmacology</topic><topic>glycosides</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Inhibitory Concentration 50</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phosphodiesterase I</topic><topic>phytochemicals</topic><topic>plant extracts</topic><topic>Plants, Medicinal - chemistry</topic><topic>spectral analysis</topic><topic>stereochemistry</topic><topic>stilbenes</topic><topic>Stilbenes - chemistry</topic><topic>Stilbenes - isolation & purification</topic><topic>Stilbenes - pharmacology</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>triterpenoids</topic><topic>xanthine oxidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atta-ur-Rahman</creatorcontrib><creatorcontrib>Naz, H</creatorcontrib><creatorcontrib>Fadimatou</creatorcontrib><creatorcontrib>Makhmoor, T</creatorcontrib><creatorcontrib>Yasin, A</creatorcontrib><creatorcontrib>Fatima, N</creatorcontrib><creatorcontrib>Ngounou, F.N</creatorcontrib><creatorcontrib>Kimbu, S.F</creatorcontrib><creatorcontrib>Sondengam, B.L</creatorcontrib><creatorcontrib>Choudhary, M.I</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atta-ur-Rahman</au><au>Naz, H</au><au>Fadimatou</au><au>Makhmoor, T</au><au>Yasin, A</au><au>Fatima, N</au><au>Ngounou, F.N</au><au>Kimbu, S.F</au><au>Sondengam, B.L</au><au>Choudhary, M.I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive constituents from Boswellia papyrifera</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>68</volume><issue>2</issue><spage>189</spage><epage>193</epage><pages>189-193</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), beta-elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10). The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>15730241</pmid><doi>10.1021/np040142x</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2005-02, Vol.68 (2), p.189-193 |
| issn | 0163-3864 1520-6025 |
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| source | MEDLINE; ACS Publications |
| subjects | Biological and medical sciences Boswellia Boswellia - chemistry Boswellia papyrifera Cameroon chemical structure enzyme inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology General pharmacology glycosides Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Inhibitory Concentration 50 Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phosphodiesterase I phytochemicals plant extracts Plants, Medicinal - chemistry spectral analysis stereochemistry stilbenes Stilbenes - chemistry Stilbenes - isolation & purification Stilbenes - pharmacology Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoids xanthine oxidase |
| title | Bioactive constituents from Boswellia papyrifera |
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