Bioactive constituents from Boswellia papyrifera

Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxys...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-02, Vol.68 (2), p.189-193
Hauptverfasser:	Atta-ur-Rahman, Naz, H, Fadimatou, Makhmoor, T, Yasin, A, Fatima, N, Ngounou, F.N, Kimbu, S.F, Sondengam, B.L, Choudhary, M.I
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Boswellia Boswellia - chemistry Boswellia papyrifera Cameroon chemical structure enzyme inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology General pharmacology glycosides Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Inhibitory Concentration 50 Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phosphodiesterase I phytochemicals plant extracts Plants, Medicinal - chemistry spectral analysis stereochemistry stilbenes Stilbenes - chemistry Stilbenes - isolation & purification Stilbenes - pharmacology Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoids xanthine oxidase
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Zusammenfassung:	Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), beta-elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10). The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np040142x