Kinetics of decomposition of irbesartan in aqueous solutions determined by high performance liquid chromatography

The kinetics of breakdown of irbesartan in aqueous solutions at elevated temperatures has been investigated by a high performance liquid chromatography method. The reaction is found to follow first-order kinetics and the rate constant for the degradation at 25 °C is estimated by extrapolation. The d...

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Veröffentlicht in:	Pharmazie 2004-12, Vol.59 (12), p.920-922
1. Verfasser:	Mbah, C. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antihypertensive Agents - chemistry Biphenyl Compounds - chemistry Buffers Calibration Chromatography, High Pressure Liquid Drug Stability Hydrogen-Ion Concentration Hydrolysis Kinetics Reference Standards Solutions Spectrophotometry, Infrared Temperature Tetrazoles - chemistry
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Zusammenfassung:	The kinetics of breakdown of irbesartan in aqueous solutions at elevated temperatures has been investigated by a high performance liquid chromatography method. The reaction is found to follow first-order kinetics and the rate constant for the degradation at 25 °C is estimated by extrapolation. The decomposition of irbesartan is shown to be hydroxide ion catalysed and the effects of ionic strength and buffer concentrations to such rate studies are discussed.
ISSN:	0031-7144