The role of peripheral chemoreceptor activity on the respiratory responses to hypoxia and hypercapnia in anaesthetised rabbits with induced hypothyroidism

The purpose of this study was to investigate the role of peripheral chemoreceptor activity on the hypoxic and hypercapnic ventilatory drives in rabbits with induced hypothyroidism. Experiments were carried out in control and hypothyroid rabbits. Hypothyroidism was induced by an administration of an...

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Veröffentlicht in:Chinese journal of physiology 2004-09, Vol.47 (3), p.153
Hauptverfasser: Simsek, Gonul, Yelmen, Nermin Karaturan, Guner, Ibrahim, Sahin, Gulderen, Oruc, Tulin, Karter, Yesari
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Sprache:eng
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Zusammenfassung:The purpose of this study was to investigate the role of peripheral chemoreceptor activity on the hypoxic and hypercapnic ventilatory drives in rabbits with induced hypothyroidism. Experiments were carried out in control and hypothyroid rabbits. Hypothyroidism was induced by an administration of an iodide-blocker, methimazole in food (75 mg/100 g food) for ten weeks. At the end of the tenth week, triiodothyronine (T3) and thyroxine (T4) levels significantly decreased (P
ISSN:0304-4920