Docosahexaenoic acid induces apoptosis via the bax-independent pathway in HL-60 cells

We attempted to determine whether docosahexaenoic acid (DHA)-induced apoptosis is mediated via the Baxmediated pathway in human myeloid leukemia HL-60 cells. DHA-induced apoptosis was confirmed by morphological analysis and caspase-3 activation. But, cyclosporin A (CsA), an inhibitor of mitochondria...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2004-11, Vol.68 (11), p.2415-2417
Hauptverfasser:	Miura, Y. (Okayama Univ. (Japan)), Takahara, K, Murata, Y, Utsumi, K, Tada, M, Takahata, K
Format:	Artikel
Sprache:	eng
Schlagworte:	APOPTOSIS Apoptosis - drug effects bax bcl-2-Associated X Protein Biological and medical sciences Caspase 3 Caspases - metabolism Cyclosporine - pharmacology DOCOSAHEXAENOIC ACID docosahexaenoic acid (DHA) Docosahexaenoic Acids - pharmacology Enzyme Activation - drug effects Etoposide - pharmacology Fundamental and applied biological sciences. Psychology HL-60 Cells Humans LEUKOCYTES Mitochondria - drug effects Mitochondria - metabolism MYELOMA Permeability Protein Transport - drug effects Proto-Oncogene Proteins c-bcl-2 - physiology
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Zusammenfassung:	We attempted to determine whether docosahexaenoic acid (DHA)-induced apoptosis is mediated via the Baxmediated pathway in human myeloid leukemia HL-60 cells. DHA-induced apoptosis was confirmed by morphological analysis and caspase-3 activation. But, cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition (MPT), did not inhibit DHA-induced Bax translocation to mitochondria or caspase-3 activation. These data suggest that DHA can induce apoptosis via the Bax-independent pathway.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.68.2415