The Complete Genomic Sequence of Nocardia farcinica IFM 10152
We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) b...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2004-10, Vol.101 (41), p.14925-14930 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 14930 |
|---|---|
| container_issue | 41 |
| container_start_page | 14925 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 101 |
| creator | Ishikawa, Jun Yamashita, Atsushi Mikami, Yuzuru Hoshino, Yasutaka Kurita, Haruyo Hotta, Kunimoto Shiba, Tadayoshi Hattori, Masahira Ōmura, Satoshi |
| description | We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease. |
| doi_str_mv | 10.1073/pnas.0406410101 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmed_primary_15466710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3373658</jstor_id><sourcerecordid>3373658</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-d763429025d898eb7ade6c14faf231321ddb6778e0cc9786fc6e3bbad86155d53</originalsourceid><addsrcrecordid>eNqFkTtvFDEUhS0EIstCTYOQRRGJYpLrt6dIgVZJiBSgINSWx_aQWc2MF3smSv59vNpVFmgiF7fwd-7jHITeEzghoNjpZrT5BDhITqC8F2hBoCaV5DW8RAsAqirNKT9Cb3JeA0AtNLxGR0RwKRWBBTq7uQ14FYdNH6aAL8MYh87hn-HPHEYXcGzx9-hs8p3FrU2uGztn8dXFN1ymCfoWvWptn8O7fV2iXxfnN6uv1fWPy6vVl-vKcaGnyivJOK2BCq9rHRplfZCO8Na2lBFGifeNVEoHcK5WWrZOBtY01mtJhPCCLdHZru9mbobgXRinZHuzSd1g04OJtjP__ozdrfkd74ygFLgu-uO9PsVyWZ7M0GUX-t6OIc7ZSFlLrTh5FiRKyeI1LeCn_8B1nNNYTDAUCBNSlHiW6HQHuRRzTqF92piA2eZntvmZQ35F8fHvQw_8PrAC4D2wVR7aEcOJIbymW7M-P4OYdu77KdxPhf2wY9d5iukJZkwxKTR7BHEsti8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201356507</pqid></control><display><type>article</type><title>The Complete Genomic Sequence of Nocardia farcinica IFM 10152</title><source>MEDLINE</source><source>Jstor Complete Legacy</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Ishikawa, Jun ; Yamashita, Atsushi ; Mikami, Yuzuru ; Hoshino, Yasutaka ; Kurita, Haruyo ; Hotta, Kunimoto ; Shiba, Tadayoshi ; Hattori, Masahira ; Ōmura, Satoshi</creator><creatorcontrib>Ishikawa, Jun ; Yamashita, Atsushi ; Mikami, Yuzuru ; Hoshino, Yasutaka ; Kurita, Haruyo ; Hotta, Kunimoto ; Shiba, Tadayoshi ; Hattori, Masahira ; Ōmura, Satoshi</creatorcontrib><description>We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0406410101</identifier><identifier>PMID: 15466710</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Amino Acid Sequence ; Antibiotics ; Bacteria ; Biological Sciences ; Chromosome Mapping ; Chromosomes ; Chromosomes, Bacterial - genetics ; Genes ; Genome, Bacterial ; Genomes ; Genomics ; Molecular Sequence Data ; Mycobacterium tuberculosis ; Nocardia ; Nocardia - genetics ; Nocardia farcinica ; Operons ; Proteins ; RNA Polymerase II - genetics ; Sequence Alignment ; Sequence Homology, Amino Acid</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2004-10, Vol.101 (41), p.14925-14930</ispartof><rights>Copyright 1993/2004 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Oct 12, 2004</rights><rights>Copyright © 2004, The National Academy of Sciences 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-d763429025d898eb7ade6c14faf231321ddb6778e0cc9786fc6e3bbad86155d53</citedby><cites>FETCH-LOGICAL-c458t-d763429025d898eb7ade6c14faf231321ddb6778e0cc9786fc6e3bbad86155d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/101/41.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3373658$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3373658$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,724,777,781,800,882,27905,27906,53772,53774,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15466710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishikawa, Jun</creatorcontrib><creatorcontrib>Yamashita, Atsushi</creatorcontrib><creatorcontrib>Mikami, Yuzuru</creatorcontrib><creatorcontrib>Hoshino, Yasutaka</creatorcontrib><creatorcontrib>Kurita, Haruyo</creatorcontrib><creatorcontrib>Hotta, Kunimoto</creatorcontrib><creatorcontrib>Shiba, Tadayoshi</creatorcontrib><creatorcontrib>Hattori, Masahira</creatorcontrib><creatorcontrib>Ōmura, Satoshi</creatorcontrib><title>The Complete Genomic Sequence of Nocardia farcinica IFM 10152</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.</description><subject>Amino Acid Sequence</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Biological Sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Chromosomes, Bacterial - genetics</subject><subject>Genes</subject><subject>Genome, Bacterial</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Molecular Sequence Data</subject><subject>Mycobacterium tuberculosis</subject><subject>Nocardia</subject><subject>Nocardia - genetics</subject><subject>Nocardia farcinica</subject><subject>Operons</subject><subject>Proteins</subject><subject>RNA Polymerase II - genetics</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Amino Acid</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtvFDEUhS0EIstCTYOQRRGJYpLrt6dIgVZJiBSgINSWx_aQWc2MF3smSv59vNpVFmgiF7fwd-7jHITeEzghoNjpZrT5BDhITqC8F2hBoCaV5DW8RAsAqirNKT9Cb3JeA0AtNLxGR0RwKRWBBTq7uQ14FYdNH6aAL8MYh87hn-HPHEYXcGzx9-hs8p3FrU2uGztn8dXFN1ymCfoWvWptn8O7fV2iXxfnN6uv1fWPy6vVl-vKcaGnyivJOK2BCq9rHRplfZCO8Na2lBFGifeNVEoHcK5WWrZOBtY01mtJhPCCLdHZru9mbobgXRinZHuzSd1g04OJtjP__ozdrfkd74ygFLgu-uO9PsVyWZ7M0GUX-t6OIc7ZSFlLrTh5FiRKyeI1LeCn_8B1nNNYTDAUCBNSlHiW6HQHuRRzTqF92piA2eZntvmZQ35F8fHvQw_8PrAC4D2wVR7aEcOJIbymW7M-P4OYdu77KdxPhf2wY9d5iukJZkwxKTR7BHEsti8</recordid><startdate>20041012</startdate><enddate>20041012</enddate><creator>Ishikawa, Jun</creator><creator>Yamashita, Atsushi</creator><creator>Mikami, Yuzuru</creator><creator>Hoshino, Yasutaka</creator><creator>Kurita, Haruyo</creator><creator>Hotta, Kunimoto</creator><creator>Shiba, Tadayoshi</creator><creator>Hattori, Masahira</creator><creator>Ōmura, Satoshi</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20041012</creationdate><title>The Complete Genomic Sequence of Nocardia farcinica IFM 10152</title><author>Ishikawa, Jun ; Yamashita, Atsushi ; Mikami, Yuzuru ; Hoshino, Yasutaka ; Kurita, Haruyo ; Hotta, Kunimoto ; Shiba, Tadayoshi ; Hattori, Masahira ; Ōmura, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-d763429025d898eb7ade6c14faf231321ddb6778e0cc9786fc6e3bbad86155d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amino Acid Sequence</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Biological Sciences</topic><topic>Chromosome Mapping</topic><topic>Chromosomes</topic><topic>Chromosomes, Bacterial - genetics</topic><topic>Genes</topic><topic>Genome, Bacterial</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Molecular Sequence Data</topic><topic>Mycobacterium tuberculosis</topic><topic>Nocardia</topic><topic>Nocardia - genetics</topic><topic>Nocardia farcinica</topic><topic>Operons</topic><topic>Proteins</topic><topic>RNA Polymerase II - genetics</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Amino Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishikawa, Jun</creatorcontrib><creatorcontrib>Yamashita, Atsushi</creatorcontrib><creatorcontrib>Mikami, Yuzuru</creatorcontrib><creatorcontrib>Hoshino, Yasutaka</creatorcontrib><creatorcontrib>Kurita, Haruyo</creatorcontrib><creatorcontrib>Hotta, Kunimoto</creatorcontrib><creatorcontrib>Shiba, Tadayoshi</creatorcontrib><creatorcontrib>Hattori, Masahira</creatorcontrib><creatorcontrib>Ōmura, Satoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishikawa, Jun</au><au>Yamashita, Atsushi</au><au>Mikami, Yuzuru</au><au>Hoshino, Yasutaka</au><au>Kurita, Haruyo</au><au>Hotta, Kunimoto</au><au>Shiba, Tadayoshi</au><au>Hattori, Masahira</au><au>Ōmura, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Complete Genomic Sequence of Nocardia farcinica IFM 10152</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2004-10-12</date><risdate>2004</risdate><volume>101</volume><issue>41</issue><spage>14925</spage><epage>14930</epage><pages>14925-14930</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>15466710</pmid><doi>10.1073/pnas.0406410101</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2004-10, Vol.101 (41), p.14925-14930 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmed_primary_15466710 |
| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Antibiotics Bacteria Biological Sciences Chromosome Mapping Chromosomes Chromosomes, Bacterial - genetics Genes Genome, Bacterial Genomes Genomics Molecular Sequence Data Mycobacterium tuberculosis Nocardia Nocardia - genetics Nocardia farcinica Operons Proteins RNA Polymerase II - genetics Sequence Alignment Sequence Homology, Amino Acid |
| title | The Complete Genomic Sequence of Nocardia farcinica IFM 10152 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T18%3A47%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Complete%20Genomic%20Sequence%20of%20Nocardia%20farcinica%20IFM%2010152&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Ishikawa,%20Jun&rft.date=2004-10-12&rft.volume=101&rft.issue=41&rft.spage=14925&rft.epage=14930&rft.pages=14925-14930&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.0406410101&rft_dat=%3Cjstor_pubme%3E3373658%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201356507&rft_id=info:pmid/15466710&rft_jstor_id=3373658&rfr_iscdi=true |