A novel antifungal pyrrole derivative from Datura metel leaves

Phytochemical investigation of the leaves of Datura metel Linn. led to the isolation of a new pyrrole derivative 1 which was characterised as 2β-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1′-methylethyl pentanoate on the basis of spectral data analyses and chemical reactions. Compound 1 was endowed w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmazie 2004-07, Vol.59 (7), p.568-570
Hauptverfasser:	Dabur, R., Ali, M., Singh, H., Gupta, J., Sharma, G. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Aspergillus fumigatus - drug effects Chromatography, High Pressure Liquid Chromatography, Thin Layer Datura - chemistry Electrophoresis, Polyacrylamide Gel Fungal Proteins - drug effects Indicators and Reagents Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Plant Extracts - chemistry Plant Leaves - chemistry Pyrroles - chemistry Pyrroles - isolation & purification Pyrroles - pharmacology Solvents Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Valerates - chemistry Valerates - isolation & purification Valerates - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Phytochemical investigation of the leaves of Datura metel Linn. led to the isolation of a new pyrrole derivative 1 which was characterised as 2β-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1′-methylethyl pentanoate on the basis of spectral data analyses and chemical reactions. Compound 1 was endowed with antifungal activity and its MIC was found to be 87.5 μg/ml. Two proteins having molecular weights of 42 and 58 kD of Aspergillus fumigatus are potential targets for compound 1.
ISSN:	0031-7144