Exercise hyperventilation, dyspnea sensation, and ergoreflex activation in lone atrial fibrillation

1 Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, and 2 Institute of Cardiology, University of Milan, 20144 Milan, Italy Submitted 14 May 2004 ; accepted in final form 21 July 2004 Lone atrial fibrillation may be associated with daily life disability and exercise limitation. The extracardiac pathophysiology of these effects is poorly explored. In 35 subjects with lone atrial fibrillation (mean age 67 ± 7 yr), we investigated pulmonary function, symptom-limited cardiopulmonary exercise performance, muscle ergoreflex (handgrip exercise) contribution to ventilation, and brachial artery flow-mediated dilation (as a measure of endothelial function) before and after (average interval 20 ± 5 days) restoring sinus rhythm with external cardioversion. Respiratory volumes and lung diffusing capacity at rest were within normal limits during both atrial fibrillation and after restoring sinus rhythm. Cardioversion was associated with the following changes: a decrease of the slope of exercise ventilation vs. CO 2 production (from 35 ± 5 to 29 ± 3; P < 0.01) and of dyspnea sensation (Borg score from 4 to 2) and an increase of peak oxygen uptake ( O 2 ; from 16 ± 4 to 20 ± 5 ml·min –1 ·kg –1 ; P < 0.01), O 2 at anaerobic threshold (from 11 ± 2 to 13 ± 2 ml·min –1 ·kg –1 ; P < 0.05), and O 2 pulse (from 8 ± 3 to 11 ± 3 ml/beat; P < 0.01). After cardioversion, the observed improvement in ventilatory efficiency was accompanied by a significant peak end-tidal CO 2 increase (from 33 ± 2 to 37 ± 2 mmHg; P < 0.01) and no changes in dead space-to-tidal volume ratio (from 0.23 ± 0.03 to 0.23 ± 0.02; P = not significant). In addition, the ergoreflex contribution to ventilation was remarkably attenuated, and the brachial artery flow-mediated dilatation was significantly augmented (from 0.32 ± 0.07 to 0.42 ± 0.08 mm; P < 0.01). Ten patients had atrial fibrillation relapse and, compared with values after restoration of regular sinus rhythm, invariably showed worsening of endothelial function, exercise ventilatory efficiency, and muscle ergoreflex contribution to ventilation. In subjects with lone atrial fibrillation, an impairment in ventilatory efficiency appears to be involved in the pathophysiology of exercise limitation, and to be primarily related with a demodulated peripheral control of ventilation. lone atrial fibrillation; exercise; ventilation; dyspnea Address for reprint requests and other correspondence: M. Guazzi, Cardiopulmonary L