Gefitinib as Salvage Therapy in Pretreated Patients with Advanced Non-small Cell Lung Cancer. Data from a Compassionate Use Program
Purpose: To evaluate the tolerability and activity of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with pretreated advanced non-small cell lung cancer (NSCLC). Materials and Methods: From July 2001 to August 2003, we analysed, retrospectively, the data of 125...
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Veröffentlicht in: | Anticancer research 2004-05, Vol.24 (3B), p.1873-1877 |
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Zusammenfassung: | Purpose: To evaluate the tolerability and activity of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor,
in patients with pretreated advanced non-small cell lung cancer (NSCLC). Materials and Methods: From July 2001 to August 2003,
we analysed, retrospectively, the data of 125 previously treated advanced NSCLC patients receiving gefitinib 250 mg orally
once daily in a compassionate use program. Results: Main toxicity was (% of patients): grade 1-2 skin changes in 7 (5.6%)
and 8 (6.4%) patients, respectively. Grade 1 diarrhea in 16 (12.8%) patients. Grade 1 and 2 hypertransaminasemia in 1 (0.8%)
patient, respectively. Grade 2 onychopathy in 1 (0.8%) patient and epistaxis in 1 (0.8%) case. There were 1 complete response
(0.8%), 6 partial responses (4.8%) and 22 (17.6%) stable disease with an overall control of disease in 23.2% of cases. Median
progression-free survival and overall survival were 8.8 and 21.5 weeks, respectively. Conclusion: Gefitinib is active, feasible
and well-tolerated in pretreated patients affected by advanced NSCLC. |
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ISSN: | 0250-7005 1791-7530 |