Gefitinib as Salvage Therapy in Pretreated Patients with Advanced Non-small Cell Lung Cancer. Data from a Compassionate Use Program

Purpose: To evaluate the tolerability and activity of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with pretreated advanced non-small cell lung cancer (NSCLC). Materials and Methods: From July 2001 to August 2003, we analysed, retrospectively, the data of 125...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Anticancer research 2004-05, Vol.24 (3B), p.1873-1877
Hauptverfasser: GRIDELLI, Cesare, ROSSI, Antonio, MAIONE, Paolo, GUERRIERO, Ciro, AIROMA, Giuseppe, COLANTUONI, Giuseppe, BARZELLONI, Maria Luisa
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Purpose: To evaluate the tolerability and activity of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with pretreated advanced non-small cell lung cancer (NSCLC). Materials and Methods: From July 2001 to August 2003, we analysed, retrospectively, the data of 125 previously treated advanced NSCLC patients receiving gefitinib 250 mg orally once daily in a compassionate use program. Results: Main toxicity was (% of patients): grade 1-2 skin changes in 7 (5.6%) and 8 (6.4%) patients, respectively. Grade 1 diarrhea in 16 (12.8%) patients. Grade 1 and 2 hypertransaminasemia in 1 (0.8%) patient, respectively. Grade 2 onychopathy in 1 (0.8%) patient and epistaxis in 1 (0.8%) case. There were 1 complete response (0.8%), 6 partial responses (4.8%) and 22 (17.6%) stable disease with an overall control of disease in 23.2% of cases. Median progression-free survival and overall survival were 8.8 and 21.5 weeks, respectively. Conclusion: Gefitinib is active, feasible and well-tolerated in pretreated patients affected by advanced NSCLC.
ISSN:0250-7005
1791-7530