Hemodynamic effects of calcitonin in the normal rat

Hemodynamic effects of calcitonin in the normal rat

Calcitonin (CT) was administered acutely (IV 4–8 U/kg) and chronically ( SC 2 U/kg/day × 150 day ) to normal male rats. Measurements included heart rate (HR), mean blood pressure (MBP), cardiac index (CI), peripheral vascular resistance (PVR), and stroke volume index (SVI). The MBP was higher in CT...

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Veröffentlicht in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1992-05, Vol.13 (3), p.571-575
Hauptverfasser: Peguero-Rivera, Alfredo M., Corder, Clinton N.
Format: Artikel
Sprache:eng
Schlagworte:
Anesthesia, General
Animals
Biochemistry & Molecular Biology
Biological and medical sciences
Blood pressure
Blood Pressure - drug effects
Calcitonin
Calcitonin - pharmacology
Cardiac output
Cardiac Output - drug effects
Catheters, Indwelling
Endocrinology & Metabolism
Fundamental and applied biological sciences. Psychology
Hemodynamics - drug effects
Hemodynamics. Rheology
Injections, Intravenous
Injections, Subcutaneous
Life Sciences & Biomedicine
Male
Pharmacology & Pharmacy
Rat
Rats
Rats, Inbred Strains
Science & Technology
Transducers
Vertebrates: cardiovascular system
Wakefulness - physiology
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Zusammenfassung:Calcitonin (CT) was administered acutely (IV 4–8 U/kg) and chronically ( SC 2 U/kg/day × 150 day ) to normal male rats. Measurements included heart rate (HR), mean blood pressure (MBP), cardiac index (CI), peripheral vascular resistance (PVR), and stroke volume index (SVI). The MBP was higher in CT rats examined under pentobarbital anesthesia. Upon awakening from anesthesia, rats chronically on CT exhibited impaired recovery of CI and SVI. Hemodynamic effects were not seen in rats acutely treated with CT. Heart weight was unchanged in chronic treatment with CT. Therefore, CT had minimal hemodynamic effects in the normal male rat.
ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(92)90091-G