Myc Degradation: Dancing with Ubiquitin Ligases

The F-box protein Fbw7 appears to mediate recognition and ubiquitination fo the c-Myc transcription factor when the latter is phosphorylated on the Thr 58. Recent research in the understanding of the posttranslational modifications regulating Myc turnover in vivo and another F-box protein Skp2 in My...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-06, Vol.101 (24), p.8843-8844
1. Verfasser:	Amati, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Commentaries DNA Enzymes F box proteins Gene expression regulation Genetic mutation Humans Medical research Molecular biology Phosphorylation Proteins Proto-Oncogene Proteins c-myc - chemistry Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism S-Phase Kinase-Associated Proteins - metabolism Transcriptional activation Tumors Ubiquitin-Protein Ligases - metabolism Ubiquitins Ubiquitins - metabolism
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Beschreibung
Zusammenfassung:	The F-box protein Fbw7 appears to mediate recognition and ubiquitination fo the c-Myc transcription factor when the latter is phosphorylated on the Thr 58. Recent research in the understanding of the posttranslational modifications regulating Myc turnover in vivo and another F-box protein Skp2 in Myc regulation are also discussed.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.0403046101