Structure of Vaccinia Complement Protein in Complex with Heparin and Potential Implications for Complement Regulation

Vaccinia virus complement control protein (VCP), a homolog of the regulators of the complement activation family of proteins, inhibits complement activation through mechanisms similar to human fluid-phase complement regulators factor H and C4b-binding protein. VCP has a heparin-binding activity that...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-06, Vol.101 (24), p.8924-8929
Hauptverfasser:	Ganesh, Vannakambadi K., Smith, Scott A., Kotwal, Girish J., Krishna H. M. Murthy, Springer, Timothy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Atomic interactions Atoms Biological Sciences Biophysics Complement activation Complement C3b - metabolism Complement Factor H - genetics Complement Factor H - metabolism Crystal structure Crystallography, X-Ray Hemolytic uremic syndrome Heparin Heparin - chemistry Heparin - metabolism Ligands Models, Molecular Molecular Sequence Data Molecules Peptide Fragments - chemistry Peptide Fragments - metabolism Physiological regulation Protein Binding Protein Conformation Proteins Regulator genes Vaccinia Vaccinia virus Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism
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