Contrast-Dependent Spatial Summation in the Lateral Geniculate Nucleus and Retina of the Cat

Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 Submitted 25 February 2004; accepted in final form 27 April 2004 Based on extracellular recordings from 69 lateral geniculate nucleus (LGN) cells in the anesthetized cat, we found spatial summation within their receptive fields to be dependent on the contrast of the stimuli presented. By fitting the summation curves to a difference of Gaussians model, we attributed this contrast-dependent effect to an actual change in the size of the center mechanism. Analogous changes in spatial frequency tuning were also observed, specifically increased peaks and cut-off frequencies with contrast. These effects were seen across the populations of both X and Y cell types. In a few cases, LGN cells were recorded simultaneously with one of their retinal ganglion cell (RGC) inputs (S-potentials). In every case, the RGCs exhibited similar contrast-dependent effects in the space and spatial-frequency domains. We propose that this contrast dependency in the retinal ganglion cells results directly from a reduction in the size of the center mechanism due to an increase in contrast. We also propose that these properties first arise in the retina and are transmitted passively through the LGN to visual cortex. Address for reprint requests and other correspondence: M. J. Nolt, 215 Stemmler Hall, Dept. of Neuroscience, School of Medicine, Univ. of Pennsylvania, Philadelphia, PA 19104-6060 (E-mail: nolt{at}mail.med.upenn.edu ).