Qualitative and quantitative analysis of three amino acid derivatives of anticonvulsant activity

Qualitative and quantitative methods of analysis of three new amino-acid derivatives potential anticonvulsants of low neurotoxicity: picolinic acid benzylamide (1), nicotinic acid benzylamide (2) and isonicotinic acid benzylamide (3) were developed. Qualitative analysis includes characteristic react...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2003-09, Vol.60 (5), p.335
Hauptverfasser:	Pirianowicz-Chaber, Elzbieta, Goldnik, Anna, Paruszewski, Ryszard
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - analysis Anticonvulsants - chemistry Benzyl Compounds - analysis Benzyl Compounds - chemistry Chromatography, High Pressure Liquid - methods Niacin - analogs & derivatives Niacin - analysis Niacin - chemistry Picolinic Acids - analysis Picolinic Acids - chemistry Sensitivity and Specificity Spectrophotometry - methods
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Beschreibung
Zusammenfassung:	Qualitative and quantitative methods of analysis of three new amino-acid derivatives potential anticonvulsants of low neurotoxicity: picolinic acid benzylamide (1), nicotinic acid benzylamide (2) and isonicotinic acid benzylamide (3) were developed. Qualitative analysis includes characteristic reactions, chromatographic (TLC) investigations, IR and UV spectra interpretation. The quantitative analysis involves spectophotometric, chromatographic (HPLC) and acidimetric methods.
ISSN:	0001-6837