Cytotoxic effects of sesquiterpene lactones from the flowers of Hemisteptia lyrata B

Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8alpha-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia lyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolat...

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Veröffentlicht in:	Archives of pharmacal research 2003-11, Vol.26 (11), p.925
Hauptverfasser:	Ha, Tae Joung, Jang, Dae Sik, Lee, Jong Rok, Lee, Kyung Dong, Lee, Jun, Hwang, Seon Woo, Jung, Hwa Jin, Nam, Sang Hae, Park, Ki Hun, Yang, Min Suk
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - toxicity Asteraceae Cell Line, Tumor Drug Screening Assays, Antitumor - methods Flowers - toxicity Humans Lactones - chemistry Lactones - isolation & purification Lactones - toxicity Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - toxicity Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - toxicity
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Zusammenfassung:	Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8alpha-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia lyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines.
ISSN:	0253-6269
DOI:	10.1007/BF02980201