Deletions of 17p and p53 mutations in preneoplastic lesions of the lung

Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the pr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1992-11, Vol.52 (21), p.6079-6082
Hauptverfasser:	SOZZI, G, MIOZZO, M, DONGHI, R, PILOTTI, S, CARIANI, C. T, PASTORINO, U, DELLA MORTA, G, PIEROTTI, M. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Carcinoma in Situ - genetics Carcinoma, Squamous Cell - genetics Chromosome Deletion Chromosomes, Human, Pair 17 Genes, p53 - genetics Humans Lung Neoplasms - genetics Medical sciences Molecular Sequence Data Pneumology Precancerous Conditions - genetics Tumors of the respiratory system and mediastinum
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Zusammenfassung:	Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis.
ISSN:	0008-5472 1538-7445