Purine Analogs as Feedback Inhibitors.

Summary Accumulation of ribotide of 5-amino-4-imidazole carboxamide (AICAR), excreted in the riboside form by a purine-requiring mutant of Escherichia coli, was inhibited by a number of structural analogs of purines. The most potent inhibitors were 6-thioguanine, 6-mercaptopurine, and 2,6-diaminopur...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1959-08, Vol.101 (4), p.641-643
Hauptverfasser:	Gots, Joseph S., Gollub, Edith G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites Humans Purines - antagonists & inhibitors
Online-Zugang:	Volltext
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